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Literature summary extracted from

  • Baker, D.A.; Deng, W.
    Cyclic GMP-dependent protein kinases in protozoa (2005), Front. Biosci., 10, 1229-1238.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 8-NBD-cGMP i.e. 8-[[2-[(7-nitro-4-benzofurazanyl)amino]ethyl]thio]guanosine-3',5'-cyclic monophosphate, poor, non-cooperative binding Eimeria tenella
2.7.11.12 cGMP
-
 Chlamydomonas reinhardtii
2.7.11.12 cGMP
-
 Homo sapiens
2.7.11.12 cGMP
-
 Bos taurus
2.7.11.12 cGMP
-
 Aplysia californica
2.7.11.12 cGMP
-
 Caenorhabditis elegans
2.7.11.12 cGMP
-
 Tetrahymena sp.
2.7.11.12 cGMP
-
 Plasmodium yoelii
2.7.11.12 cGMP
-
 Drosophila melanogaster
2.7.11.12 cGMP
-
 Cryptosporidium parvum
2.7.11.12 cGMP
-
 Eimeria maxima
2.7.11.12 cGMP
-
 Hydra oligactis
2.7.11.12 cGMP
-
 Apis mellifera
2.7.11.12 cGMP
-
 Paramecium tetraurelia
2.7.11.12 cGMP binding site analysis, positive cooperativity at low concentration Plasmodium falciparum
2.7.11.12 cGMP binding site analysis, positive cooperativity at low concentration Paramecium tetraurelia
2.7.11.12 cGMP highly activating, binding site analysis Toxoplasma gondii
2.7.11.12 cGMP highly activating, binding site analysis, cooperative binding Eimeria tenella

Application

EC Number Application Comment Organism
2.7.11.12 drug development enzyme is a target for drug development Eimeria tenella
2.7.11.12 drug development enzyme is a target for drug development Toxoplasma gondii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.12 expression of tagged enzyme in Escherichia coli, mutational analaysis, phylogenetic analysis Plasmodium falciparum
2.7.11.12 expression of tagged enzyme in Escherichia coli, mutational analaysis, phylogenetic analysis Paramecium tetraurelia
2.7.11.12 phylogenetic analysis Chlamydomonas reinhardtii
2.7.11.12 phylogenetic analysis Aplysia californica
2.7.11.12 phylogenetic analysis Caenorhabditis elegans
2.7.11.12 phylogenetic analysis Plasmodium yoelii
2.7.11.12 phylogenetic analysis Drosophila melanogaster
2.7.11.12 phylogenetic analysis Cryptosporidium parvum
2.7.11.12 phylogenetic analysis Toxoplasma gondii
2.7.11.12 phylogenetic analysis Eimeria maxima
2.7.11.12 phylogenetic analysis Hydra oligactis
2.7.11.12 phylogenetic analysis Apis mellifera
2.7.11.12 phylogenetic analysis, expression in Toxoplasma gondii Eimeria tenella

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 4-[2-(fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine inhibitor of apicomplexan parasite enzyme, IC50 is 1 nM for the enzyme of Eimeria tenella, mechanism Eimeria tenella
2.7.11.12 4-[2-(fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine inhibitor of apicomplexan parasite enzyme, mechanism Toxoplasma gondii
2.7.11.12 KT5926
-
 Eimeria tenella
2.7.11.12 KT5926
-
 Toxoplasma gondii
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Apis mellifera
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Aplysia californica
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Bos taurus
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Caenorhabditis elegans
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Chlamydomonas reinhardtii
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Cryptosporidium parvum
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Drosophila melanogaster
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Eimeria maxima
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence ERKVQKAIKQQE Eimeria tenella
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Homo sapiens
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Hydra oligactis
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence; the enzyme possesses an N-terminal autoinhibitory sequence ERNKKKAIFSND Paramecium tetraurelia
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence ERNKKKAIFSND Plasmodium falciparum
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Plasmodium yoelii
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Tetrahymena sp.
2.7.11.12 additional information the enzyme possesses an N-terminal autoinhibitory sequence Toxoplasma gondii
2.7.11.12 staurosporine
-
 Eimeria tenella
2.7.11.12 staurosporine
-
 Toxoplasma gondii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.12 113000 125000 gel filtration Eimeria tenella

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 additional information Apis mellifera the enzyme is involved in age-dependent behavioural change from nurse to a foraging way of life by increased gene amfor expression ?
-
 ?
2.7.11.12 additional information Plasmodium falciparum the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release ?
-
 ?
2.7.11.12 additional information Paramecium tetraurelia the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release ?
-
 ?
2.7.11.12 additional information Eimeria tenella the enzyme is involved in gliding motility and cell invasion ?
-
 ?
2.7.11.12 additional information Toxoplasma gondii the enzyme is involved in gliding motility and cell invasion ?
-
 ?
2.7.11.12 additional information Drosophila melanogaster the enzyme is involved in locomotion behaviour of the larvae in presence of food, so-called rover and sitter gene ecoding an isozyme termed forager, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Apis mellifera Q8SSX4 gene amfor
-
2.7.11.12 Aplysia californica
-
-
-
2.7.11.12 Bos taurus
-
 isozyme PKG-Ialpha
-
2.7.11.12 Caenorhabditis elegans
-
-
-
2.7.11.12 Chlamydomonas reinhardtii
-
-
-
2.7.11.12 Cryptosporidium parvum Q8MMZ6
-
-
2.7.11.12 Drosophila melanogaster P32023
-
-
2.7.11.12 Eimeria maxima Q8MMZ5
-
-
2.7.11.12 Eimeria tenella Q8MMZ8 single gene encoded enzyme
-
2.7.11.12 Homo sapiens
-
 isozyme PKG-Ialpha
-
2.7.11.12 Hydra oligactis O17474
-
-
2.7.11.12 Paramecium tetraurelia Q869J9 gene PKG-2
-
2.7.11.12 Paramecium tetraurelia Q869K0 gene PKG-1
-
2.7.11.12 Plasmodium falciparum
-
-
-
2.7.11.12 Plasmodium yoelii
-
-
-
2.7.11.12 Tetrahymena sp.
-
-
-
2.7.11.12 Toxoplasma gondii Q8MMP4
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.12 phosphoprotein autophosphorylation Chlamydomonas reinhardtii
2.7.11.12 phosphoprotein autophosphorylation Aplysia californica
2.7.11.12 phosphoprotein autophosphorylation Caenorhabditis elegans
2.7.11.12 phosphoprotein autophosphorylation Tetrahymena sp.
2.7.11.12 phosphoprotein autophosphorylation Plasmodium yoelii
2.7.11.12 phosphoprotein autophosphorylation Drosophila melanogaster
2.7.11.12 phosphoprotein autophosphorylation Eimeria tenella
2.7.11.12 phosphoprotein autophosphorylation Cryptosporidium parvum
2.7.11.12 phosphoprotein autophosphorylation Toxoplasma gondii
2.7.11.12 phosphoprotein autophosphorylation Eimeria maxima
2.7.11.12 phosphoprotein autophosphorylation Hydra oligactis
2.7.11.12 phosphoprotein autophosphorylation Apis mellifera
2.7.11.12 phosphoprotein autophosphorylation Paramecium tetraurelia
2.7.11.12 phosphoprotein autophosphorylation of isozymes at a Thr in the catalytic domain is essential, phosphorylation sites, also for other kinases, overview Homo sapiens
2.7.11.12 phosphoprotein autophosphorylation of isozymes at a Thr in the catalytic domain is essential, phosphorylation sites, also for other kinases, overview Bos taurus
2.7.11.12 phosphoprotein autophosphorylation of isozymes, phosphorylation sites, also for other kinases, overview Plasmodium falciparum
2.7.11.12 phosphoprotein autophosphorylation of isozymes, phosphorylation sites, also for other kinases, overview Paramecium tetraurelia

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 sporozoite
-
 Eimeria tenella
-
2.7.11.12 tachyzoite
-
 Toxoplasma gondii
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.12 additional information
-
 the enzyme shows low basal activity Eimeria tenella
2.7.11.12 additional information
-
 the enzyme shows low basal activity Toxoplasma gondii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 additional information the enzyme is involved in age-dependent behavioural change from nurse to a foraging way of life by increased gene amfor expression Apis mellifera ?
-
 ?
2.7.11.12 additional information the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release Plasmodium falciparum ?
-
 ?
2.7.11.12 additional information the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release Paramecium tetraurelia ?
-
 ?
2.7.11.12 additional information the enzyme is involved in gliding motility and cell invasion Eimeria tenella ?
-
 ?
2.7.11.12 additional information the enzyme is involved in gliding motility and cell invasion Toxoplasma gondii ?
-
 ?
2.7.11.12 additional information the enzyme is involved in locomotion behaviour of the larvae in presence of food, so-called rover and sitter gene ecoding an isozyme termed forager, overview Drosophila melanogaster ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.12 monomer 1 * 113000-125000, functional enzyme, SDS-PAGE Eimeria tenella
2.7.11.12 More domain structure Chlamydomonas reinhardtii
2.7.11.12 More domain structure Aplysia californica
2.7.11.12 More domain structure Caenorhabditis elegans
2.7.11.12 More domain structure Plasmodium falciparum
2.7.11.12 More domain structure Plasmodium yoelii
2.7.11.12 More domain structure Drosophila melanogaster
2.7.11.12 More domain structure Paramecium tetraurelia
2.7.11.12 More domain structure Eimeria tenella
2.7.11.12 More domain structure Cryptosporidium parvum
2.7.11.12 More domain structure Toxoplasma gondii
2.7.11.12 More domain structure Eimeria maxima
2.7.11.12 More domain structure Hydra oligactis
2.7.11.12 More domain structure Apis mellifera

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 PKG
-
 Chlamydomonas reinhardtii
2.7.11.12 PKG
-
 Homo sapiens
2.7.11.12 PKG
-
 Bos taurus
2.7.11.12 PKG
-
 Aplysia californica
2.7.11.12 PKG
-
 Caenorhabditis elegans
2.7.11.12 PKG
-
 Plasmodium falciparum
2.7.11.12 PKG
-
 Tetrahymena sp.
2.7.11.12 PKG
-
 Plasmodium yoelii
2.7.11.12 PKG
-
 Drosophila melanogaster
2.7.11.12 PKG
-
 Paramecium tetraurelia
2.7.11.12 PKG
-
 Eimeria tenella
2.7.11.12 PKG
-
 Cryptosporidium parvum
2.7.11.12 PKG
-
 Toxoplasma gondii
2.7.11.12 PKG
-
 Eimeria maxima
2.7.11.12 PKG
-
 Hydra oligactis
2.7.11.12 PKG
-
 Apis mellifera

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.12 0.000001
-
 inhibitor of apicomplexan parasite enzyme, IC50 is 1 nM for the enzyme of Eimeria tenella, mechanism Eimeria tenella 4-[2-(fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine