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Literature summary extracted from

  • Palancade, B.; Bensaude, O.
    Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation (2003), Eur. J. Biochem., 270, 3859-3870.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.23 nucleus
-
 Drosophila melanogaster 5634
-
2.7.11.23 nucleus
-
 Homo sapiens 5634
-
2.7.11.23 nucleus
-
 Saccharomyces cerevisiae 5634
-
2.7.11.23 nucleus
-
 Schizosaccharomyces pombe 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.23 ATP + [DNA-directed RNA polymerase] Drosophila melanogaster CTD phosphorylation and transcription cycle overview ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] Saccharomyces cerevisiae CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] Schizosaccharomyces pombe CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] Homo sapiens the CTD of the RNA polymerase II is the target for numerous enzymes, including cell cycle-dependent kinases and phosphatases, thus phosphorylation of the CTD becomes a key event during mRNA metabolism and physiological regulation of transcription, and is affected by cell stress or embryonic development, CTD phosphorylation and transcription cycle overview ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 additional information Homo sapiens phosphorylation of CTD is required to disrupt the interactions between unphosphorylated CTD and the mediator complex to form a holoenzyme of RNA polymerase II or with transcription factors to form a preinitiation complex of transcription, disruption of the interactions at elongation of transcription are required to assist the recruitment of pre-mRNA modification enzymes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.23 Drosophila melanogaster
-
-
-
2.7.11.23 Homo sapiens
-
-
-
2.7.11.23 Saccharomyces cerevisiae
-
-
-
2.7.11.23 Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.23 ATP + [DNA-directed RNA polymerase] CTD phosphorylation and transcription cycle overview Drosophila melanogaster ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview Saccharomyces cerevisiae ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] CTD phosphorylation facilitates pre-mRNA processing, CTD phosphorylation and transcription cycle overview Schizosaccharomyces pombe ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] the CTD of the RNA polymerase II is the target for numerous enzymes, including cell cycle-dependent kinases and phosphatases, thus phosphorylation of the CTD becomes a key event during mRNA metabolism and physiological regulation of transcription, and is affected by cell stress or embryonic development, CTD phosphorylation and transcription cycle overview Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, e.g. at Ser2 and Ser5, overview Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, e.g. at Ser5, overview Saccharomyces cerevisiae ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, overview Drosophila melanogaster ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, the CTD phosphorylation pattern is precisely modified as RNA polymerase II progresses along the genes and is involved in sequential recruitment of RNA processing factors, multiple phosphorylation sites and epitopes, overview Schizosaccharomyces pombe ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
2.7.11.23 additional information phosphorylation of CTD is required to disrupt the interactions between unphosphorylated CTD and the mediator complex to form a holoenzyme of RNA polymerase II or with transcription factors to form a preinitiation complex of transcription, disruption of the interactions at elongation of transcription are required to assist the recruitment of pre-mRNA modification enzymes Homo sapiens ?
-
 ?
2.7.11.23 additional information cyclin-dependent kinase Cdk1, Cdk7, and Cdk9, EC 2.7.11.22, and by MAPK, EC 2.7.11.24, phosphorylating specific serine residues Homo sapiens ?
-
 ?
2.7.11.23 additional information the reaction is also in vitro performed by cyclin-dependent kinase Ctk1, and Bur1, EC 2.7.11.22, phosphorylating specific serine residues Saccharomyces cerevisiae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.23 Cdk1
-
 Homo sapiens
2.7.11.23 cdk7
-
 Homo sapiens
2.7.11.23 CDK9
-
 Homo sapiens
2.7.11.23 CTD kinase
-
 Drosophila melanogaster
2.7.11.23 CTD kinase
-
 Homo sapiens
2.7.11.23 CTD kinase
-
 Saccharomyces cerevisiae
2.7.11.23 CTD kinase
-
 Schizosaccharomyces pombe
2.7.11.23 MAPK
-
 Homo sapiens
2.7.11.23 More see also EC 2.7.11.22 and EC 2.7.11.24 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.23 ATP
-
 Drosophila melanogaster
2.7.11.23 ATP
-
 Homo sapiens
2.7.11.23 ATP
-
 Saccharomyces cerevisiae
2.7.11.23 ATP
-
 Schizosaccharomyces pombe