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Literature summary extracted from

  • Simon, V.; Robin, M.T.; Legrand, C.; Cohen-Tannoudji, J.
    Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells (2003), Endocrinology, 144, 3058-3066.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.16 transient overexpression of wild-types and dominant negative mutants of GRK5 and GRK6 in COS-7 cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.16 K215R inactive dominant negative mutants of GRK5 or GRK6, overexpression of the GRK5 mutant in myometrial cells does not influence beta-adrenergic receptor sensitivity, while overexpression of GRK6 mutant leads to a 70% increase in isoproterenol-stimulated beta-adrenergic signaling via the beta-adrenergic receptor Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.16 heparin GRK inhibitor Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.16 Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.16 additional information Rattus norvegicus the GRK4-6 family member enzymes mediate beta-adrenergic receptor desensitization, the beta-adrenergic receptor is stimulated by agonists such as isoproterenol, cholera toxin, or forskolin, and induces cAMP production ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.16 Rattus norvegicus
-
Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.16 myometrium primary cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.16 ATP + rhodopsin urea treated outer segments of rhodopsin Rattus norvegicus ADP + phosphorylated rhodopsin
-
?
2.7.11.16 additional information the GRK4-6 family member enzymes mediate beta-adrenergic receptor desensitization, the beta-adrenergic receptor is stimulated by agonists such as isoproterenol, cholera toxin, or forskolin, and induces cAMP production Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.16 G protein-coupled receptor kinase 5
-
Rattus norvegicus
2.7.11.16 G protein-coupled receptor kinase 6
-
Rattus norvegicus
2.7.11.16 GRK5
-
Rattus norvegicus
2.7.11.16 GRK6
-
Rattus norvegicus
2.7.11.16 More the enzyme belongs to the GRK4-6 family Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.16 30
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.16 7.5
-
assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.16 ATP
-
Rattus norvegicus