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Literature summary extracted from

  • Hollosy, F.; Keri, G.
    Plant-derived protein tyrosine kinase inhibitors as anticancer agents (2004), Curr. Med. Chem. Anticancer Agents, 4, 173-197.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.10.2 drug development non-receptor PTKs are targets for design by computational chemistry of therapeutic agents based on plant-derived inhibitors from ethnopharmaceutical knowledge, high-throughput screening, tyrosine kinase inhibitors can target the ATP or the substrate binding sites, respectively, strategies, detailed overview Homo sapiens
2.7.10.2 pharmacology non-receptor PTKs are targets for inhibitors as anticancer agents Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 1-azaanthraquinones
-
Homo sapiens
2.7.10.2 1-methyl-emodin inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 2-chloro-omega-hydroxy-emodin inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 8-methyl-emodin inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 acacetin inhibition of p56lck Homo sapiens
2.7.10.2 apigenin inhibition of p56lck Homo sapiens
2.7.10.2 catenarin i.e. 4-hydroxy-emodin, inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 chrysin inhibition of p56lck Homo sapiens
2.7.10.2 damnacanthal an anthraquinone, strong and selective inhibition of p56lck Homo sapiens
2.7.10.2 datiscetin inhibition of p56lck Homo sapiens
2.7.10.2 emodic acid inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 emodin inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 emodin derivatives synthetic analogues, inhibition of p56lck and Src, overview Homo sapiens
2.7.10.2 endocrocin inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 fisetin inhibition of p56lck Homo sapiens
2.7.10.2 flavone derivatives inhibition of p56lck, overview Homo sapiens
2.7.10.2 galangin inhibition of p56lck Homo sapiens
2.7.10.2 genkwanin inhibition of p56lck Homo sapiens
2.7.10.2 kaempferide inhibition of p56lck Homo sapiens
2.7.10.2 kaempferol inhibition of p56lck Homo sapiens
2.7.10.2 kaempferol-3-O-arabinoside slight inhibition of p56lck Homo sapiens
2.7.10.2 kaempferol-3-O-rhamnoside slight inhibition of p56lck Homo sapiens
2.7.10.2 luteolin inhibition of p56lck Homo sapiens
2.7.10.2 additional information analysis of inhibitory potential and cytotoxic effects of a large number of plant-derived secondary metabolites on PTKs and human tumor cell lines, respectively, overview Homo sapiens
2.7.10.2 morin inhibition of p56lck Homo sapiens
2.7.10.2 myricetin inhibition of p56lck Homo sapiens
2.7.10.2 nevadensin inhibition of p56lck Homo sapiens
2.7.10.2 paeciloquinone A inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 Paeciloquinone B inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 paeciloquinone C inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 paeciloquinone D inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 piceatannol inhibition of p56lck Homo sapiens
2.7.10.2 purpurin inhibition of p56lck and c-Src Homo sapiens
2.7.10.2 quercetin inhibition of p56lck Homo sapiens
2.7.10.2 resokaempferol inhibition of p56lck Homo sapiens
2.7.10.2 resveratrol inhibition of p56lck Homo sapiens
2.7.10.2 stilbene derivatives inhibition of p56lck, overview Homo sapiens
2.7.10.2 syringetin inhibition of p56lck Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 cytoplasm
-
Homo sapiens 5737
-
2.7.10.2 additional information cytoplasmic PTKs are cytoplasmic, nuclear, or anchored to the inner leaflet of the plasma membrane Homo sapiens
-
-
2.7.10.2 nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 cell culture
-
Homo sapiens
-
2.7.10.2 thymocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [peptide]-L-tyrosine
-
Homo sapiens ADP + a [peptide]-L-tyrosine phosphate
-
?
2.7.10.2 ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 AL
-
Homo sapiens
2.7.10.2 cytoplasmic protein tyrosine kinase
-
Homo sapiens
2.7.10.2 Fgr
-
Homo sapiens
2.7.10.2 FPS
-
Homo sapiens
2.7.10.2 Lck
-
Homo sapiens
2.7.10.2 More non-receptor PTKs are grouped into several families and subfamilies Homo sapiens
2.7.10.2 non-receptor protein tyrosine kinase
-
Homo sapiens
2.7.10.2 p56lck
-
Homo sapiens
2.7.10.2 Protein tyrosine kinase
-
Homo sapiens
2.7.10.2 PTK
-
Homo sapiens
2.7.10.2 Src
-
Homo sapiens
2.7.10.2 Yes
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
Homo sapiens