EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.10.2 | drug development | non-receptor PTKs are targets for design by computational chemistry of therapeutic agents based on plant-derived inhibitors from ethnopharmaceutical knowledge, high-throughput screening, tyrosine kinase inhibitors can target the ATP or the substrate binding sites, respectively, strategies, detailed overview | Homo sapiens |
2.7.10.2 | pharmacology | non-receptor PTKs are targets for inhibitors as anticancer agents | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | 1-azaanthraquinones | - |
Homo sapiens | |
2.7.10.2 | 1-methyl-emodin | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | 2-chloro-omega-hydroxy-emodin | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | 8-methyl-emodin | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | acacetin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | apigenin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | catenarin | i.e. 4-hydroxy-emodin, inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | chrysin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | damnacanthal | an anthraquinone, strong and selective inhibition of p56lck | Homo sapiens | |
2.7.10.2 | datiscetin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | emodic acid | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | emodin | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | emodin derivatives | synthetic analogues, inhibition of p56lck and Src, overview | Homo sapiens | |
2.7.10.2 | endocrocin | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | fisetin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | flavone derivatives | inhibition of p56lck, overview | Homo sapiens | |
2.7.10.2 | galangin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | genkwanin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | kaempferide | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | kaempferol | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | kaempferol-3-O-arabinoside | slight inhibition of p56lck | Homo sapiens | |
2.7.10.2 | kaempferol-3-O-rhamnoside | slight inhibition of p56lck | Homo sapiens | |
2.7.10.2 | luteolin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | additional information | analysis of inhibitory potential and cytotoxic effects of a large number of plant-derived secondary metabolites on PTKs and human tumor cell lines, respectively, overview | Homo sapiens | |
2.7.10.2 | morin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | myricetin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | nevadensin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | paeciloquinone A | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | Paeciloquinone B | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | paeciloquinone C | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | paeciloquinone D | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | piceatannol | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | purpurin | inhibition of p56lck and c-Src | Homo sapiens | |
2.7.10.2 | quercetin | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | resokaempferol | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | resveratrol | inhibition of p56lck | Homo sapiens | |
2.7.10.2 | stilbene derivatives | inhibition of p56lck, overview | Homo sapiens | |
2.7.10.2 | syringetin | inhibition of p56lck | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.10.2 | cytoplasm | - |
Homo sapiens | 5737 | - |
2.7.10.2 | additional information | cytoplasmic PTKs are cytoplasmic, nuclear, or anchored to the inner leaflet of the plasma membrane | Homo sapiens | - |
- |
2.7.10.2 | nucleus | - |
Homo sapiens | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.2 | ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.10.2 | cell culture | - |
Homo sapiens | - |
2.7.10.2 | thymocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.2 | ATP + a [peptide]-L-tyrosine | - |
Homo sapiens | ADP + a [peptide]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.2 | AL | - |
Homo sapiens |
2.7.10.2 | cytoplasmic protein tyrosine kinase | - |
Homo sapiens |
2.7.10.2 | Fgr | - |
Homo sapiens |
2.7.10.2 | FPS | - |
Homo sapiens |
2.7.10.2 | Lck | - |
Homo sapiens |
2.7.10.2 | More | non-receptor PTKs are grouped into several families and subfamilies | Homo sapiens |
2.7.10.2 | non-receptor protein tyrosine kinase | - |
Homo sapiens |
2.7.10.2 | p56lck | - |
Homo sapiens |
2.7.10.2 | Protein tyrosine kinase | - |
Homo sapiens |
2.7.10.2 | PTK | - |
Homo sapiens |
2.7.10.2 | Src | - |
Homo sapiens |
2.7.10.2 | Yes | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | ATP | - |
Homo sapiens |