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Literature summary extracted from

  • Magni, G.; Amici, A.; Emanuelli, M.; Orsomando, G.; Raffaelli, N.; Ruggieri, S.
    Structure and function of nicotinamide mononucleotide adenylyltransferase (2004), Curr. Med. Chem., 11, 873-885.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.1 additional information SO42- has no effect Methanocaldococcus jannaschii
2.7.7.1 SO42- 0.1 M, 20fold activation Saccharolobus solfataricus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.1 ADP-ribose
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.1 0.023
-
 NAD+ isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 0.073
-
 NAD+ isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 0.083
-
 diphosphate isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 0.11
-
 nicotinamide ribonucleotide isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 0.13
-
 nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 0.19
-
 ATP isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 1.4
-
 ATP isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 5
-
 diphosphate isoform yNMNAT-2 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.1 Co2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 Co2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 Mg2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 Mg2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 Mn2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 Mn2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 Ni2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 Ni2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
2.7.7.1 Zn2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 Zn2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.1 18600
-
 x * 18600, SDS-PAGE Saccharolobus solfataricus
2.7.7.1 19600
-
 x * 19600, SDS-PAGE Methanocaldococcus jannaschii
2.7.7.1 46000
-
 4 * 46000, isoform yNMNAT-2, SDS-PAGE Saccharomyces cerevisiae
2.7.7.1 48000
-
 4 * 48000, isoform yNMNAT-1, SDS-PAGE Saccharomyces cerevisiae
2.7.7.1 66000
-
-
 Saccharolobus solfataricus
2.7.7.1 72000
-
-
 Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Haemophilus influenzae final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Bacillus subtilis final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Saccharomyces cerevisiae final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Bos taurus final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Methanothermobacter thermautotrophicus final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Saccharolobus solfataricus final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Methanocaldococcus jannaschii final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Bacillus subtilis
-
-
-
2.7.7.1 Bos taurus
-
-
-
2.7.7.1 Haemophilus influenzae
-
-
-
2.7.7.1 Homo sapiens
-
-
-
2.7.7.1 Methanocaldococcus jannaschii
-
-
-
2.7.7.1 Methanothermobacter thermautotrophicus
-
-
-
2.7.7.1 Saccharolobus solfataricus
-
-
-
2.7.7.1 Saccharomyces cerevisiae
-
 isoform yNMNAT-1
-
2.7.7.1 Saccharomyces cerevisiae
-
 isoform yNMNAT-2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.1
-
 Homo sapiens
2.7.7.1
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 corpus luteum activity is high during mid luteal phase, when corpora lutea are mature with respect to structure and function, while it dramatically decreases following PGF2alpha analog injection Bos taurus
-
2.7.7.1 placenta
-
 Homo sapiens
-
2.7.7.1 testis
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Haemophilus influenzae diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Bacillus subtilis diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Bos taurus diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Methanothermobacter thermautotrophicus diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Saccharolobus solfataricus diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Methanocaldococcus jannaschii diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Haemophilus influenzae diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Bacillus subtilis diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Bos taurus diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Methanothermobacter thermautotrophicus diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Saccharolobus solfataricus diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Methanocaldococcus jannaschii diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide isoform yNMNAT-1 Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
2.7.7.1 CTP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide cytosine dinucleotide
-
 ?
2.7.7.1 dATP + nicotinamide ribonucleotide isoform yNMNAT-1 Saccharomyces cerevisiae diphosphate + ?
-
 ?
2.7.7.1 dATP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide deoxyadenosine dinucleotide
-
 ?
2.7.7.1 GTP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide guanine dinucleotide
-
 ?
2.7.7.1 ITP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide hypoxanthine dinucleotide
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.1 ? x * 18600, SDS-PAGE Saccharolobus solfataricus
2.7.7.1 ? x * 19600, SDS-PAGE Methanocaldococcus jannaschii
2.7.7.1 hexamer
-
 Methanothermobacter thermautotrophicus
2.7.7.1 hexamer
-
 Methanocaldococcus jannaschii
2.7.7.1 tetramer
-
 Haemophilus influenzae
2.7.7.1 tetramer 4 * 46000, isoform yNMNAT-2, SDS-PAGE Saccharomyces cerevisiae
2.7.7.1 tetramer 4 * 48000, isoform yNMNAT-1, SDS-PAGE Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 hNMNAT-1
-
 Homo sapiens
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Haemophilus influenzae
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Bacillus subtilis
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Homo sapiens
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Saccharomyces cerevisiae
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Bos taurus
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Methanothermobacter thermautotrophicus
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Saccharolobus solfataricus
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Methanocaldococcus jannaschii
2.7.7.1 NMNAT
-
 Haemophilus influenzae
2.7.7.1 NMNAT
-
 Bacillus subtilis
2.7.7.1 NMNAT
-
 Saccharomyces cerevisiae
2.7.7.1 NMNAT
-
 Bos taurus
2.7.7.1 NMNAT
-
 Methanothermobacter thermautotrophicus
2.7.7.1 NMNAT
-
 Saccharolobus solfataricus
2.7.7.1 NMNAT
-
 Methanocaldococcus jannaschii
2.7.7.1 yNMNAT-1
-
 Saccharomyces cerevisiae
2.7.7.1 yNMNAT-2
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.1 90
-
 above Methanocaldococcus jannaschii
2.7.7.1 97
-
 above Saccharolobus solfataricus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.7.1 90
-
 half-life is 30 min Saccharolobus solfataricus
2.7.7.1 90
-
 half-life is 1 h Methanocaldococcus jannaschii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.1 5.8 7.8
-
 Saccharolobus solfataricus
2.7.7.1 6.5 8 isoform yNMNAT-2 Saccharomyces cerevisiae
2.7.7.1 7 8.5 isoform yNMNAT-1 Saccharomyces cerevisiae

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.7.1 Saccharomyces cerevisiae 4.2, 4.9 and 6.2, isoform yNMNAT-1
-
 4.2
2.7.7.1 Saccharomyces cerevisiae predicted, isoform yNMNAT-2
-
 5.6