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Literature summary extracted from

  • Kee, T.H.; Vit, P.; Melendez, A.J.
    Sphingosine kinase signalling in immune cells (2005), Clin. Exp. Pharmacol. Physiol., 32, 153-161.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.91
-
 Drosophila melanogaster
2.7.1.91
-
 Saccharomyces cerevisiae
2.7.1.91
-
 Tetrahymena pyriformis
2.7.1.91
-
 Arabidopsis thaliana
2.7.1.91
-
 Caenorhabditis elegans
2.7.1.91 DNA and amino acid sequence determination and analysis Mus musculus
2.7.1.91 DNA and amino acid sequence determination and analysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 DL-threo-dihydrosphingosine
-
 Homo sapiens
2.7.1.91 DL-threo-dihydrosphingosine
-
 Mus musculus
2.7.1.91 N,N-dimethylsphingosine
-
 Homo sapiens
2.7.1.91 N,N-dimethylsphingosine
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 cytosol
-
 Mus musculus 5829
-
2.7.1.91 cytosol
-
 Homo sapiens 5829
-
2.7.1.91 extracellular
-
 Mus musculus
-
-
2.7.1.91 extracellular
-
 Homo sapiens
-
-
2.7.1.91 additional information subcellular localization depends on the tissue type Mus musculus
-
-
2.7.1.91 additional information subcellular localization depends on the tissue type Homo sapiens
-
-
2.7.1.91 nucleus
-
 Mus musculus 5634
-
2.7.1.91 nucleus
-
 Homo sapiens 5634
-
2.7.1.91 plasma membrane
-
 Mus musculus 5886
-
2.7.1.91 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.91 ATP + D-erythro-sphingosine Mus musculus
-
 ADP + D-erythro-sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + D-erythro-sphingosine Homo sapiens
-
 ADP + D-erythro-sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + phytosphingosine Mus musculus
-
 ADP + phytosphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + phytosphingosine Homo sapiens
-
 ADP + phytosphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphinganine Mus musculus
-
 ADP + sphinganine 1-phosphate
-
 ?
2.7.1.91 ATP + sphinganine Homo sapiens
-
 ADP + sphinganine 1-phosphate
-
 ?
2.7.1.91 ATP + sphingosine Drosophila melanogaster
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine Mus musculus
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine Homo sapiens
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine Saccharomyces cerevisiae
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine Tetrahymena pyriformis
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine Arabidopsis thaliana
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine Caenorhabditis elegans
-
 ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 additional information Homo sapiens the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes ?
-
 ?
2.7.1.91 additional information Mus musculus the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Arabidopsis thaliana
-
-
-
2.7.1.91 Caenorhabditis elegans
-
-
-
2.7.1.91 Drosophila melanogaster
-
-
-
2.7.1.91 Homo sapiens
-
 2 isozymes SPHK1 and SPHK2
-
2.7.1.91 Mus musculus
-
 2 isozymes SPHK1 and SPHK2
-
2.7.1.91 Saccharomyces cerevisiae
-
-
-
2.7.1.91 Tetrahymena pyriformis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.91 isozyme SPHK1 Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism Drosophila melanogaster
a
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism Saccharomyces cerevisiae
a
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism Tetrahymena pyriformis
a
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism Arabidopsis thaliana
a
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism Caenorhabditis elegans
a
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism, the catalytic domain contains the C1-C5 sequence stretches and the ATP-binding site Mus musculus
a
2.7.1.91 ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate catalytic mechanism, the catalytic domain contains the C1-C5 sequence stretches and the ATP-binding site Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 blood platelet
-
 Mus musculus
-
2.7.1.91 blood platelet
-
 Homo sapiens
-
2.7.1.91 brain white matter, cerebellum, cerebrum, red nucleus, cerebral peduncle Mus musculus
-
2.7.1.91 brain white matter, cerebellum, cerebrum, red nucleus, cerebral peduncle Homo sapiens
-
2.7.1.91 cerebellum
-
 Mus musculus
-
2.7.1.91 cerebellum
-
 Homo sapiens
-
2.7.1.91 cerebrum
-
 Mus musculus
-
2.7.1.91 cerebrum
-
 Homo sapiens
-
2.7.1.91 endothelium
-
 Mus musculus
-
2.7.1.91 endothelium
-
 Homo sapiens
-
2.7.1.91 heart
-
 Mus musculus
-
2.7.1.91 heart
-
 Homo sapiens
-
2.7.1.91 kidney
-
 Mus musculus
-
2.7.1.91 kidney
-
 Homo sapiens
-
2.7.1.91 leukocyte of peripheral blood Mus musculus
-
2.7.1.91 leukocyte of peripheral blood Homo sapiens
-
2.7.1.91 liver
-
 Mus musculus
-
2.7.1.91 liver
-
 Homo sapiens
-
2.7.1.91 lung
-
 Mus musculus
-
2.7.1.91 lung
-
 Homo sapiens
-
2.7.1.91 megacaryocyte
-
 Homo sapiens
-
2.7.1.91 megakaryocyte
-
 Mus musculus
-
2.7.1.91 additional information isozyme tissue distribution Mus musculus
-
2.7.1.91 additional information isozyme tissue distribution Homo sapiens
-
2.7.1.91 neutrophil
-
 Homo sapiens
-
2.7.1.91 spleen
-
 Mus musculus
-
2.7.1.91 spleen
-
 Homo sapiens
-
2.7.1.91 thymus
-
 Mus musculus
-
2.7.1.91 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + D-erythro-sphingosine
-
 Mus musculus ADP + D-erythro-sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + D-erythro-sphingosine
-
 Homo sapiens ADP + D-erythro-sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + phytosphingosine
-
 Mus musculus ADP + phytosphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + phytosphingosine
-
 Homo sapiens ADP + phytosphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphinganine
-
 Mus musculus ADP + sphinganine 1-phosphate
-
 ?
2.7.1.91 ATP + sphinganine
-
 Homo sapiens ADP + sphinganine 1-phosphate
-
 ?
2.7.1.91 ATP + sphingosine
-
 Drosophila melanogaster ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Mus musculus ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Saccharomyces cerevisiae ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Tetrahymena pyriformis ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Arabidopsis thaliana ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Caenorhabditis elegans ADP + sphingosine 1-phosphate
-
 ir
2.7.1.91 ATP + sphingosine
-
 Drosophila melanogaster ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine
-
 Mus musculus ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine
-
 Saccharomyces cerevisiae ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine
-
 Tetrahymena pyriformis ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine
-
 Arabidopsis thaliana ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 ATP + sphingosine
-
 Caenorhabditis elegans ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview ir
2.7.1.91 additional information the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes Homo sapiens ?
-
 ?
2.7.1.91 additional information the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 sphinganine kinase
-
 Drosophila melanogaster
2.7.1.91 sphinganine kinase
-
 Mus musculus
2.7.1.91 sphinganine kinase
-
 Homo sapiens
2.7.1.91 sphinganine kinase
-
 Saccharomyces cerevisiae
2.7.1.91 sphinganine kinase
-
 Tetrahymena pyriformis
2.7.1.91 sphinganine kinase
-
 Arabidopsis thaliana
2.7.1.91 sphinganine kinase
-
 Caenorhabditis elegans
2.7.1.91 SPHK
-
 Drosophila melanogaster
2.7.1.91 SPHK
-
 Mus musculus
2.7.1.91 SPHK
-
 Homo sapiens
2.7.1.91 SPHK
-
 Saccharomyces cerevisiae
2.7.1.91 SPHK
-
 Tetrahymena pyriformis
2.7.1.91 SPHK
-
 Arabidopsis thaliana
2.7.1.91 SPHK
-
 Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
 Drosophila melanogaster
2.7.1.91 ATP
-
 Mus musculus
2.7.1.91 ATP
-
 Homo sapiens
2.7.1.91 ATP
-
 Saccharomyces cerevisiae
2.7.1.91 ATP
-
 Tetrahymena pyriformis
2.7.1.91 ATP
-
 Arabidopsis thaliana
2.7.1.91 ATP
-
 Caenorhabditis elegans