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Literature summary extracted from

  • Elling, L.; Rupprath, C.; Gunther, N.; Romer, U.; Verseck, S.; Weingarten, P.; Drager, G.; Kirschning, A.; Piepersberg, W.
    An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose (2005), ChemBioChem, 6, 1423-1430.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.133 synthesis development and evaluation of a modular system for large scale production of important dTDP-activated deoxyhexoses from dTMP and sucrose, overview Salmonella enterica
5.1.3.13 synthesis the enzyme is part of an enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose Salmonella enterica

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.133 gene rmlD, expression in Escherichia coli strain BL21(DE3) Salmonella enterica
5.1.3.13 expression in Escherichia coli Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.133 dTDP-6-deoxy-L-mannose + NADP+ Salmonella enterica biosynthetic pathway, overview dTDP-4-dehydro-6-deoxy-L-mannose + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.133 Salmonella enterica
-
 serovar typhimurium, LT2, gene rmlD
-
5.1.3.13 Salmonella enterica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.133 dTDP-6-deoxy-L-mannose + NADP+
-
 Salmonella enterica dTDP-4-dehydro-6-deoxy-L-mannose + NADPH
-
 ?
1.1.1.133 dTDP-6-deoxy-L-mannose + NADP+ biosynthetic pathway, overview Salmonella enterica dTDP-4-dehydro-6-deoxy-L-mannose + NADPH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.133 4-ketoreductase
-
 Salmonella enterica
1.1.1.133 RmlD
-
 Salmonella enterica
5.1.3.13 RmlC
-
 Salmonella enterica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.133 30
-
 assay at Salmonella enterica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.133 7.8
-
 assay at Salmonella enterica

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.133 NADP+
-
 Salmonella enterica