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Literature summary extracted from

  • Lodeiro, S.; Segura, M.J.R.; Stahl, M.; Schulz-Gasch, T.; Matsuda, S.P.T.
    Oxidosqualene cyclase second-sphere residues profoundly influence the product profile (2004), ChemBioChem, 5, 1581-1585.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.8 mutants are expressed in Saccharomyces cerevisiae strain LHY4 Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
5.4.99.8 H477N produces 88% lanosterol and 12% parkeol Arabidopsis thaliana
5.4.99.8 H477Q produces 22% lanosterol, 73% parkeol, and 5% 9-beta-delta-7-lanosterol Arabidopsis thaliana
5.4.99.8 I481V produces 54% cycloartenol, 25% lanosterol, and 21% parkeol Arabidopsis thaliana
5.4.99.8 Y410T produces 65% lanosterol, 2% parkeol, and 33% 9-beta-delta-7-lanosterol Arabidopsis thaliana
5.4.99.8 Y410T/H477N/I481V produces 78% lanosterol and 22% 9-beta-delta-7-lanosterol Arabidopsis thaliana
5.4.99.8 Y410T/H477Q/I481V produces 78% lanosterol and 22% 9-beta-delta-7-lanosterol Arabidopsis thaliana
5.4.99.8 Y410T/I481V produces 78% lanosterol, less than 1% parkeol, and 22% 9-beta-delta-7-lanosterol Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.8 (S)-2,3-oxidosqualene Arabidopsis thaliana
-
 cycloartenol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.8 Arabidopsis thaliana P38605
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.8 (S)-2,3-oxidosqualene
-
 Arabidopsis thaliana cycloartenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.8 cycloartenol synthase
-
 Arabidopsis thaliana