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Literature summary extracted from

  • Luo, B.; Regier, D.S.; Prescott, S.M.; Topham, M.K.
    Diacylglycerol kinases (2004), Cell. Signal., 16, 983-989.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.107 additional information serotonin signalling activates the enzyme Caenorhabditis elegans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.107
-
 Arabidopsis thaliana
2.7.1.107
-
 Caenorhabditis elegans
2.7.1.107
-
 Drosophila melanogaster
2.7.1.107
-
 Mammalia
2.7.1.107 expression of the isolated catalytic subunit of isozyme alpha shows 60% of maximal wild-type full length enzyme activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.107 additional information the ATP binding sequence of isozyme DGK2in strain rdgA contains the mutant GXDXXG motif leading to rapid retinal degeneration after birth Drosophila melanogaster
2.7.1.107 additional information mutation of the second glycine in the binding sequence motif GXGXXG of the ATP-binding site to aspartate or alanine renders the mutant enzymes catalytically inactive Mammalia
2.7.1.107 additional information mutation of the second glycine in the binding sequence motif GXGXXG of the ATP-binding site to aspartate or alanine renders the mutant enzymes catalytically inactive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 cytosol
-
 Caenorhabditis elegans 5829
-
2.7.1.107 cytosol
-
 Drosophila melanogaster 5829
-
2.7.1.107 cytosol
-
 Arabidopsis thaliana 5829
-
2.7.1.107 cytosol
-
 Mammalia 5829
-
2.7.1.107 cytosol
-
 Homo sapiens 5829
-
2.7.1.107 membrane
-
 Caenorhabditis elegans 16020
-
2.7.1.107 membrane
-
 Drosophila melanogaster 16020
-
2.7.1.107 membrane
-
 Arabidopsis thaliana 16020
-
2.7.1.107 additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Caenorhabditis elegans
-
-
2.7.1.107 additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Drosophila melanogaster
-
-
2.7.1.107 additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Arabidopsis thaliana
-
-
2.7.1.107 additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Mammalia
-
-
2.7.1.107 additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Homo sapiens
-
-
2.7.1.107 perinuclear space
-
 Mammalia
-
-
2.7.1.107 perinuclear space
-
 Homo sapiens
-
-
2.7.1.107 plasma membrane isozyme alpha Mammalia 5886
-
2.7.1.107 plasma membrane isozyme alpha Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.107 Mg2+
-
 Arabidopsis thaliana
2.7.1.107 Mg2+
-
 Caenorhabditis elegans
2.7.1.107 Mg2+
-
 Drosophila melanogaster
2.7.1.107 Mg2+
-
 Homo sapiens
2.7.1.107 Mg2+
-
 Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacylglycerol Caenorhabditis elegans the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid, isozyme dgk-1 regulates diacylglycerol signalling required for acetylcholine release ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol Drosophila melanogaster the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol Arabidopsis thaliana the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol Mammalia the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol Homo sapiens the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 additional information Caenorhabditis elegans complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
 ?
2.7.1.107 additional information Drosophila melanogaster complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
 ?
2.7.1.107 additional information Arabidopsis thaliana complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
 ?
2.7.1.107 additional information Mammalia complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
 ?
2.7.1.107 additional information Homo sapiens the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Arabidopsis thaliana
-
-
-
2.7.1.107 Caenorhabditis elegans
-
-
-
2.7.1.107 Drosophila melanogaster
-
-
-
2.7.1.107 Homo sapiens
-
 9 different isozymes divided into 5 subtypes, alternative splicing of isozymes
-
2.7.1.107 Mammalia
-
 9 different isozymes divided into 5 subtypes, alternative splicing of isozymes
-
2.7.1.107 no activity in Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 T-lymphocyte
-
 Mammalia
-
2.7.1.107 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid, isozyme dgk-1 regulates diacylglycerol signalling required for acetylcholine release Caenorhabditis elegans ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Drosophila melanogaster ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Arabidopsis thaliana ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Mammalia ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Caenorhabditis elegans ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Drosophila melanogaster ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Arabidopsis thaliana ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Mammalia ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
2.7.1.107 additional information complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Caenorhabditis elegans ?
-
 ?
2.7.1.107 additional information complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Drosophila melanogaster ?
-
 ?
2.7.1.107 additional information complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Arabidopsis thaliana ?
-
 ?
2.7.1.107 additional information complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Mammalia ?
-
 ?
2.7.1.107 additional information the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.107 additional information structure-function relationships of isozyme domain motifs, overview Caenorhabditis elegans
2.7.1.107 additional information structure-function relationships of isozyme domain motifs, overview Drosophila melanogaster
2.7.1.107 additional information structure-function relationships of isozyme domain motifs, overview Arabidopsis thaliana
2.7.1.107 additional information structure-function relationships of isozyme domain motifs, e.g. the C1 domain, the EF hand, and the pleckstrin homology, structural motifs and their organization, mammalian isozymes require other domain in addition to the catalytic domain for activity, overview Mammalia
2.7.1.107 additional information structure-function relationships of isozyme domain motifs, e.g. the C1 domain, the EF hand, and the pleckstrin homology, structural motifs and their organization, mammalian isozymes require other domain in addition to the catalytic domain for activity, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGK
-
 Caenorhabditis elegans
2.7.1.107 DGK
-
 Drosophila melanogaster
2.7.1.107 DGK
-
 Arabidopsis thaliana
2.7.1.107 DGK
-
 Mammalia
2.7.1.107 DGK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
 Caenorhabditis elegans
2.7.1.107 ATP the binding sequence contains the GXGXXG motif essential for activity Drosophila melanogaster
2.7.1.107 ATP
-
 Arabidopsis thaliana
2.7.1.107 ATP the binding sequence contains the GXGXXG motif essential for activity Mammalia
2.7.1.107 ATP the binding sequence contains the GXGXXG motif essential for activity Homo sapiens