BRENDA - Enzyme Database show

Inhibition of human lanosterol synthase by the constituents of Colocasia esculenta (taro)

Sakano, Y.; Mutsuga, M.; Tanaka, R.; Suganuma, H.; Inakuma, T.; Toyoda, M.; Goda, Y.; Shibuya, M.; Ebizuka, Y.; Biol. Pharm. Bull. 28, 299-304 (2005)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
5.4.99.7
expression in Saccharomyces cerevisiae
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
ethanol extract from Angelica keiskei leaves
11% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Basella rubra leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium flowers
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium leaves
7% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Colocasia esculenta rhizomes
55% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Cryptotaenia japonica leaves
10% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Glycine max immature seeds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Oenanthe stolonifera leaves
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Perilla frutescens leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Petasites japonicus buds
6% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale buds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale rhizomes
6% inhibition at 0.3 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.4.99.7
(3S)-2,3-oxidosqualene
Homo sapiens
-
lanosterol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.4.99.7
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.4.99.7
-
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.99.7
(3S)-2,3-oxidosqualene
-
661306
Homo sapiens
lanosterol
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.99.7
expression in Saccharomyces cerevisiae
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
ethanol extract from Angelica keiskei leaves
11% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Basella rubra leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium flowers
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium leaves
7% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Colocasia esculenta rhizomes
55% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Cryptotaenia japonica leaves
10% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Glycine max immature seeds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Oenanthe stolonifera leaves
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Perilla frutescens leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Petasites japonicus buds
6% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale buds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale rhizomes
6% inhibition at 0.3 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.4.99.7
(3S)-2,3-oxidosqualene
Homo sapiens
-
lanosterol
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.99.7
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.99.7
(3S)-2,3-oxidosqualene
-
661306
Homo sapiens
lanosterol
-
-
-
?