BRENDA - Enzyme Database

Inhibition of human lanosterol synthase by the constituents of Colocasia esculenta (taro)

Sakano, Y.; Mutsuga, M.; Tanaka, R.; Suganuma, H.; Inakuma, T.; Toyoda, M.; Goda, Y.; Shibuya, M.; Ebizuka, Y.; Biol. Pharm. Bull. 28, 299-304 (2005)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Cloned (Commentary)
Organism
5.4.99.7
expression in Saccharomyces cerevisiae
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
ethanol extract from Angelica keiskei leaves
11% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Basella rubra leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium flowers
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium leaves
7% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Colocasia esculenta rhizomes
55% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Cryptotaenia japonica leaves
10% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Glycine max immature seeds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Oenanthe stolonifera leaves
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Perilla frutescens leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Petasites japonicus buds
6% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale buds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale rhizomes
6% inhibition at 0.3 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
5.4.99.7
(3S)-2,3-oxidosqualene
Homo sapiens
-
lanosterol
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
5.4.99.7
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Purification (Commentary)
Organism
5.4.99.7
-
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
5.4.99.7
(3S)-2,3-oxidosqualene
-
661306
Homo sapiens
lanosterol
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
5.4.99.7
lanosterol synthase
-
Homo sapiens
5.4.99.7
OSC
-
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.99.7
expression in Saccharomyces cerevisiae
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
ethanol extract from Angelica keiskei leaves
11% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Basella rubra leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium flowers
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Chrysanthemum morifolium leaves
7% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Colocasia esculenta rhizomes
55% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Cryptotaenia japonica leaves
10% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Glycine max immature seeds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Oenanthe stolonifera leaves
13% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Perilla frutescens leaves
5% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Petasites japonicus buds
6% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale buds
14% inhibition at 0.3 mg/ml
Homo sapiens
5.4.99.7
ethanol extract from Zingiber officinale rhizomes
6% inhibition at 0.3 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
5.4.99.7
(3S)-2,3-oxidosqualene
Homo sapiens
-
lanosterol
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.99.7
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
5.4.99.7
(3S)-2,3-oxidosqualene
-
661306
Homo sapiens
lanosterol
-
-
-
?