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Literature summary extracted from

  • Gallois-Montbrun, S.; Faraj, A.; Seclaman, E.; Sommadossi, J.P.; Deville-Bonne, D.; Veron, M.
    Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs (2004), Biochem. Pharmacol., 68, 1749-1756.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.2.3 0.15
-
 L-GTP
-
 Homo sapiens
2.7.2.3 0.3
-
 L-ATP
-
 Homo sapiens
2.7.2.3 0.5
-
 D-GTP
-
 Homo sapiens
2.7.2.3 0.5
-
 D-ATP
-
 Homo sapiens
2.7.2.3 1
-
 L-2'-dGTP
-
 Homo sapiens
2.7.2.3 1.5
-
 L-CTP
-
 Homo sapiens
2.7.2.3 2.5
-
 L-2'-dCTP
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.3 additional information Homo sapiens the enzyme may be involved in the cellular activation of several antiviral nucleoside analogs including dideoxyinosine, acyclovir, L-2'-deoxycytosine and L-2'-deoxythymidine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.3 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.3 2',3'-didehydro-2',3'-dideoxythymidine triphosphate + 3-phospho-D-glycerate
-
 Homo sapiens 2',3'-didehydro-2',3'-dideoxythymidine diphosphate + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 2',3'-dideoxy-GTP + 3-phospho-D-glycerate
-
 Homo sapiens 2',3'-dideoxy-GDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 2'-dATP + 3-phospho-D-glycerate
-
 Homo sapiens 2'-dADP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 2'-deoxycytidine 5'-triphosphate + 3-phospho-D-glycerate
-
 Homo sapiens 2'-deoxycytidine 5'-diphosphate + 1,3-diphosphoglycerate
-
 ?
2.7.2.3 2'-dGTP + 3-phospho-D-glycerate
-
 Homo sapiens 2'-dGDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 2'-dTTP + 3-phospho-D-glycerate
-
 Homo sapiens 2'-dTDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 3'-deoxy-3'-azidothymidine triphosphate + 3-phospho-D-glycerate
-
 Homo sapiens 3'-deoxy-3'-azidothymidine diphosphate + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 acyclovir triphosphate + 3-phospho-D-glycerate
-
 Homo sapiens acyclovir diphosphate + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 D-ATP + 3-phospho-D-glycerate
-
 Homo sapiens D-ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 D-CTP + 3-phospho-D-glycerate
-
 Homo sapiens D-CDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 D-GTP + 3-phospho-D-glycerate
-
 Homo sapiens D-GDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-2'-dATP + 3-phospho-D-glycerate
-
 Homo sapiens L-2'-dADP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-2'-dCTP + 3-phospho-D-glycerate
-
 Homo sapiens L-2'-dCDP + 3-phospho-D-glyceroyl phosphate
-
 r
2.7.2.3 L-2'-dGTP + 3-phospho-D-glycerate
-
 Homo sapiens L-2'-dGDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-2'-dTTP + 3-phospho-D-glycerate
-
 Homo sapiens L-2'-dTDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-ATP + 3-phospho-D-glycerate
-
 Homo sapiens L-ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-CTP + 3-phospho-D-glycerate
-
 Homo sapiens L-CDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-GTP + 3-phospho-D-glycerate
-
 Homo sapiens L-GDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 L-UTP + 3-phospho-D-glycerate
-
 Homo sapiens L-UDP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 additional information the enzyme may be involved in the cellular activation of several antiviral nucleoside analogs including dideoxyinosine, acyclovir, L-2'-deoxycytosine and L-2'-deoxythymidine Homo sapiens ?
-
 ?
2.7.2.3 UTP + 3-phospho-D-glycerate
-
 Homo sapiens UDP + 3-phospho-D-glyceroyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.2.3 hPGK
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.2.3 4
-
 2'-dCTP
-
 Homo sapiens
2.7.2.3 10
-
 CTP
-
 Homo sapiens
2.7.2.3 100
-
 L-ATP
-
 Homo sapiens
2.7.2.3 110
-
 2'-dGTP
-
 Homo sapiens
2.7.2.3 120
-
 L-GTP
-
 Homo sapiens
2.7.2.3 420
-
 D-GTP
-
 Homo sapiens
2.7.2.3 500
-
 D-ATP
-
 Homo sapiens