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Literature summary extracted from

  • Correia, T.; Papayannopoulos, V.; Panin, V.; Woronoff, P.; Jiang, J.; Vogt, T.F.; Irvine, K.D.
    Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila (2003), Proc. Natl. Acad. Sci. USA, 100, 6404-6409.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.222 gene fng, DNA and amino acid sequence determination and analysis Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.222 D327N EMS mutagenesis, transheterozygote, mutation on allele 14, lethal phenotype Drosophila melanogaster
2.4.1.222 E220K EMS mutagenesis, transheterozygote, mutation on allele 3, lethal phenotype Drosophila melanogaster
2.4.1.222 G295D EMS mutagenesis, transheterozygote, mutation on allele L81, lethal phenotype Drosophila melanogaster
2.4.1.222 K196E EMS mutagenesis, transheterozygote, mutation on allele 11, lethal phenotype Drosophila melanogaster
2.4.1.222 K196N EMS mutagenesis, transheterozygote, mutation on allele 11, lethal phenotype Drosophila melanogaster
2.4.1.222 L213F EMS mutagenesis, transheterozygote, mutation on allele L83, lethal phenotype Drosophila melanogaster
2.4.1.222 L398Q EMS mutagenesis, transheterozygote, mutation on allele 2, phenotype overview Drosophila melanogaster
2.4.1.222 additional information construction and genetic analysis of mutated alleles, several mutants with introduced stop codons, mutant phenotypes analysis, mutants show altered wing vein numbers and structure, overview Drosophila melanogaster
2.4.1.222 S350T EMS mutagenesis, transheterozygote, mutation on allele 1, lethal phenotype Drosophila melanogaster
2.4.1.222 T184M EMS mutagenesis, transheterozygote, phenotype overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.222 Notch + UDP-D-GlcNAc Drosophila melanogaster enzyme modulates signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor-like domains beta-D-glucosaminyl-Notch + UDP
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?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.222 Drosophila melanogaster Q24324
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.222 Notch + UDP-D-GlcNAc enzyme modulates signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor-like domains Drosophila melanogaster beta-D-glucosaminyl-Notch + UDP
-
?
2.4.1.222 Notch + UDP-D-GlcNAc Notch protein is O-fucosylated at a serine or threonine residue in the epidermal growth factor-like domain Drosophila melanogaster beta-D-glucosaminyl-Notch + UDP
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?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.222 beta1,3-N-acetylglucosaminyltransferase
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Drosophila melanogaster
2.4.1.222 FNG
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Drosophila melanogaster
2.4.1.222 Fringe protein
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Drosophila melanogaster