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Literature summary extracted from

  • Matsuo, A.; Bellier, J.P.; Hisano, T.; Aimi, Y.; Yasuhara, O.; Tooyama, I.; Saito, N.; Kimura, H.
    Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation (2005), Neurochem. Int., 46, 423-433.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.6 expressed as GFP fusion protein in HEK293 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.6 cytoplasm pChAT and cChAT Rattus norvegicus 5737
-
2.3.1.6 nucleus cChAT but not pChAT, pChAT found in nucleus only after treatment with leptomycin B Rattus norvegicus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.6 49000
-
 pChAT Rattus norvegicus
2.3.1.6 69000
-
 cChAT Rattus norvegicus
2.3.1.6 76000
-
 pChAT with GFP as fusion protein Rattus norvegicus
2.3.1.6 96000
-
 cChAT with GFP as fusion protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Rattus norvegicus synthesis of the neurotransmitter acetylcholine acetylcholine + CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 neuron pChAT predominantly in peripheral neurons Rattus norvegicus
-
2.3.1.6 placenta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Rattus norvegicus acetylcholine + CoA
-
 r
2.3.1.6 acetyl-CoA + choline synthesis of the neurotransmitter acetylcholine Rattus norvegicus acetylcholine + CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.6 cChAT common choline O-acetyltransferase Rattus norvegicus
2.3.1.6 pChAT peripheral choline O-acetyltransferase, predominantly found in peripheral neurons Rattus norvegicus