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Literature summary extracted from

  • Roessner, C.A.; Huang, K.X.; Warren, M.J.; Raux, E.; Scott, A.I.
    Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. Shermanii) (2002), Microbiology, 148, 1845-1853.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.130 gene cbiL, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Salmonella enterica subsp. enterica serovar Typhimurium
2.1.1.130 gene cbiL, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Propionibacterium freudenreichii
2.1.1.131 gene cbiEGH, the gene cbiH of Propionibacterium freudenreichii is organized in a single ORF with genes cbiE and cbiG, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Propionibacterium freudenreichii
2.1.1.132 genes cbiEGH and cbiT, the gene cbiE of Propionibacterium freudenreichii is organized in a single ORF with genes cbiH and cbiG, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Propionibacterium freudenreichii
2.1.1.271 gene cbiF, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Propionibacterium freudenreichii

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.130 additional information complementation with gene cbiL of Propionibacterium freudenreichii of 2 mutants AR3711 and AR3717 of an engineered Escherichia coli strain that synthesizes cobinamide using the Salmonella typhimurium cbi genes Propionibacterium freudenreichii
2.1.1.130 additional information complementation with gene cbiL of Propionibacterium freudenreichii of 2 mutants AR3711 and AR3717 of an engineered Escherichia coli strain that synthesizes cobinamide using the Salmonella typhimurium cbi genes, overview Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.131 91400
-
x * 91400, about, cbiEGH protein, amino acid sequence calculation and SDS-PAGE Propionibacterium freudenreichii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.130 additional information Pseudomonas denitrificans (nom. rej.) the organism performs the aerobic cobalamin biosynthesis variant ?
-
?
2.1.1.130 additional information Salmonella enterica subsp. enterica serovar Typhimurium the organism performs the anaerobic cobalamin biosynthesis variant ?
-
?
2.1.1.130 additional information Propionibacterium freudenreichii the organism performs the anaerobic cobalamin biosynthesis variant ?
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 Salmonella enterica subsp. enterica serovar Typhimurium enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, overview S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 Pseudomonas denitrificans (nom. rej.) enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 Propionibacterium freudenreichii enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.131 additional information Pseudomonas denitrificans (nom. rej.) the organism performs the aerobic cobalamin biosynthesis variant ?
-
?
2.1.1.131 additional information Propionibacterium freudenreichii the organism performs the anaerobic cobalamin biosynthesis variant, the gene cbiH of Propionibacterium freudenreichii is organized in a single ORF with genes cbiE and cbiG, overview ?
-
?
2.1.1.131 S-adenosyl-L-methionine + cobalt-precorrin-3B Pseudomonas denitrificans (nom. rej.) enzyme is involved in the anaerobic cobalamin biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-4
-
?
2.1.1.131 S-adenosyl-L-methionine + cobalt-precorrin-3B Propionibacterium freudenreichii enzyme is involved in the anaerobic cobalamin biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-4
-
?
2.1.1.132 additional information Pseudomonas denitrificans (nom. rej.) the organism performs the aerobic cobalamin biosynthesis variant ?
-
?
2.1.1.132 additional information Propionibacterium freudenreichii the organism performs the anaerobic cobalamin biosynthesis variant, the gene cbiE of Propionibacterium freudenreichii is organized in a single ORF with genes cbiH and cbiG, overview ?
-
?
2.1.1.132 S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ Propionibacterium freudenreichii methylation and decarboxylation are catalyzed by 2 different enzymes in Propionibacterium freudenreichii, encoded by gene cbiE, organized in a orf/single gene with cbiG and cbiH, which is responsible for the methylations at C5 and C15, and by gene cbiT, which is responsible for the decarboxylation, steps of the anaerobic cobalamin biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
2.1.1.132 S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ Pseudomonas denitrificans (nom. rej.) steps of the aerobic cobalamin biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
2.1.1.271 additional information Pseudomonas denitrificans (nom. rej.) the organism performs the aerobic cobalamin biosynthesis variant ?
-
?
2.1.1.271 additional information Propionibacterium freudenreichii the organism performs the anaerobic cobalamin biosynthesis variant ?
-
?
2.1.1.271 S-adenosyl-L-methionine + cobalt-precorrin-4 Propionibacterium freudenreichii enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-5
-
?
2.1.1.271 S-adenosyl-L-methionine + precorrin-4 Pseudomonas denitrificans (nom. rej.) enzyme is involved in aerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview S-adenosyl-L-homocysteine + precorrin-5
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.130 Propionibacterium freudenreichii
-
i.e. Propionibacterium shermanii, gene cbiL
-
2.1.1.130 Pseudomonas denitrificans (nom. rej.)
-
gene cobI
-
2.1.1.130 Salmonella enterica subsp. enterica serovar Typhimurium
-
gene cbiL
-
2.1.1.131 Propionibacterium freudenreichii
-
i.e. Propionibacterium shermanii, gene cbiH
-
2.1.1.131 Pseudomonas denitrificans (nom. rej.)
-
gene cobJ
-
2.1.1.132 Propionibacterium freudenreichii
-
i.e. Propionibacterium shermanii, gene cbiE
-
2.1.1.132 Pseudomonas denitrificans (nom. rej.)
-
gene cobL
-
2.1.1.271 Propionibacterium freudenreichii
-
i.e. Propionibacterium shermanii, gene cbiF
-
2.1.1.271 Pseudomonas denitrificans (nom. rej.)
-
gene cobM
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.130 additional information the organism performs the aerobic cobalamin biosynthesis variant Pseudomonas denitrificans (nom. rej.) ?
-
?
2.1.1.130 additional information the organism performs the anaerobic cobalamin biosynthesis variant Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?
2.1.1.130 additional information the organism performs the anaerobic cobalamin biosynthesis variant Propionibacterium freudenreichii ?
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, overview Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 methylation at C-20 Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 methylation at C-20 Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.130 S-adenosyl-L-methionine + cobalt-precorrin-2 methylation at C-20 Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
?
2.1.1.131 additional information the organism performs the aerobic cobalamin biosynthesis variant Pseudomonas denitrificans (nom. rej.) ?
-
?
2.1.1.131 additional information the organism performs the anaerobic cobalamin biosynthesis variant, the gene cbiH of Propionibacterium freudenreichii is organized in a single ORF with genes cbiE and cbiG, overview Propionibacterium freudenreichii ?
-
?
2.1.1.131 S-adenosyl-L-methionine + cobalt-precorrin-3 C-17 methylation and ring contraction Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-4
-
?
2.1.1.131 S-adenosyl-L-methionine + cobalt-precorrin-3 C-17 methylation and ring contraction Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-4
-
?
2.1.1.131 S-adenosyl-L-methionine + cobalt-precorrin-3B enzyme is involved in the anaerobic cobalamin biosynthesis, pathway overview Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-4
-
?
2.1.1.131 S-adenosyl-L-methionine + cobalt-precorrin-3B enzyme is involved in the anaerobic cobalamin biosynthesis, pathway overview Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-4
-
?
2.1.1.132 additional information the organism performs the aerobic cobalamin biosynthesis variant Pseudomonas denitrificans (nom. rej.) ?
-
?
2.1.1.132 additional information the organism performs the anaerobic cobalamin biosynthesis variant, the gene cbiE of Propionibacterium freudenreichii is organized in a single ORF with genes cbiH and cbiG, overview Propionibacterium freudenreichii ?
-
?
2.1.1.132 S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ methylation and decarboxylation are catalyzed by 2 different enzymes in Propionibacterium freudenreichii, encoded by gene cbiE, organized in a orf/single gene with cbiG and cbiH, which is responsible for the methylations at C5 and C15, and by gene cbiT, which is responsible for the decarboxylation, steps of the anaerobic cobalamin biosynthesis, pathway overview Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
2.1.1.132 S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ steps of the aerobic cobalamin biosynthesis, pathway overview Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
2.1.1.132 S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ methylation and decarboxylation are catalyzed by 2 different enzymes in Propionibacterium freudenreichii, encoded by gene cbiE, organized in a orf/single gene with cbiG and cbiH, which is responsible for the methylations at C5 and C15, and by gene cbiT, which is responsible for the decarboxylation, overview Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
2.1.1.132 S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+ methylation at C5 and C15, and decarboxylation Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
2.1.1.271 additional information the organism performs the aerobic cobalamin biosynthesis variant Pseudomonas denitrificans (nom. rej.) ?
-
?
2.1.1.271 additional information the organism performs the anaerobic cobalamin biosynthesis variant Propionibacterium freudenreichii ?
-
?
2.1.1.271 S-adenosyl-L-methionine + cobalt-precorrin-4 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-5
-
?
2.1.1.271 S-adenosyl-L-methionine + cobalt-precorrin-4 C-11 methylation Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-5
-
?
2.1.1.271 S-adenosyl-L-methionine + precorrin-4 enzyme is involved in aerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + precorrin-5
-
?
2.1.1.271 S-adenosyl-L-methionine + precorrin-4 C-11 methylation Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + precorrin-5
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.131 ? x * 91400, about, cbiEGH protein, amino acid sequence calculation and SDS-PAGE Propionibacterium freudenreichii

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.130 S-adenosyl-L-methionine
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.1.1.130 S-adenosyl-L-methionine
-
Pseudomonas denitrificans (nom. rej.)
2.1.1.130 S-adenosyl-L-methionine
-
Propionibacterium freudenreichii