Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mihovilovic, M.D.; Kapitan, P.; Rydz, J.; Rudroff, F.; Ogink, F.H.; Fraaije, M.W.
    Biooxidation of ketones with a cyclobutanone structural motif by recombinant whole-cells expressing 4-hydroxyacetophenone monooxygenase (2005), J. Mol. Catal. B, 32, 135-140.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.84 expressed in Escherichia coli TOP10 Pseudomonas fluorescens
1.14.13.84 gene hapE, overexpression in Escherichia coli Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.84 (4-hydroxyphenyl)ethan-1-one + NADPH + O2 Pseudomonas fluorescens
-
 4-hydroxyphenyl acetate + NADP+ + H2O
-
 ?
1.14.13.84 (4-hydroxyphenyl)ethan-1-one + NADPH + O2 Pseudomonas fluorescens ACB
-
 4-hydroxyphenyl acetate + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.84 Pseudomonas fluorescens
-
-
-
1.14.13.84 Pseudomonas fluorescens
-
 gene hapE
-
1.14.13.84 Pseudomonas fluorescens ACB
-
-
-
1.14.13.84 Pseudomonas fluorescens ACB
-
 gene hapE
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.84 (4-hydroxyphenyl)ethan-1-one + NADPH + O2
-
 Pseudomonas fluorescens 4-hydroxyphenyl acetate + NADP+ + H2O
-
 ?
1.14.13.84 (4-hydroxyphenyl)ethan-1-one + NADPH + O2 Baeyer-Villiger oxidation, stereospecific reaction, regioselectivity Pseudomonas fluorescens 4-hydroxyphenyl acetate + NADP+ + H2O
-
 ?
1.14.13.84 (4-hydroxyphenyl)ethan-1-one + NADPH + O2
-
 Pseudomonas fluorescens ACB 4-hydroxyphenyl acetate + NADP+ + H2O
-
 ?
1.14.13.84 (4-hydroxyphenyl)ethan-1-one + NADPH + O2 Baeyer-Villiger oxidation, stereospecific reaction, regioselectivity Pseudomonas fluorescens ACB 4-hydroxyphenyl acetate + NADP+ + H2O
-
 ?
1.14.13.84 2-oxabicyclo[3.2.0]heptan-6-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?
1.14.13.84 2-oxabicyclo[3.2.0]heptan-6-one + NADPH + O2
-
 Pseudomonas fluorescens ACB ?
-
 ?
1.14.13.84 2-oxabicyclo[4.2.0]octan-7-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?
1.14.13.84 3-oxabicyclo[3.2.0]heptan-6-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?
1.14.13.84 bicyclo[3.2.0]hept-2-en-6-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?
1.14.13.84 bicyclo[3.2.0]hept-2-en-6-one + NADPH + O2
-
 Pseudomonas fluorescens ACB ?
-
 ?
1.14.13.84 bicyclo[3.2.0]heptan-6-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?
1.14.13.84 bicyclo[4.2.0]octan-7-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?
1.14.13.84 additional information substrate specificity, regioselectivity, the enzyme preferably and stereospecifically catalyzes Baeyer-Villiger oxidations of of ketones bearing a cyclobutanone structural motif, e.g. oxidation of several prochiral cyclobutanones to antipodal butyrolactones, overview Pseudomonas fluorescens ?
-
 ?
1.14.13.84 additional information substrate specificity, regioselectivity, the enzyme preferably and stereospecifically catalyzes Baeyer-Villiger oxidations of of ketones bearing a cyclobutanone structural motif, e.g. oxidation of several prochiral cyclobutanones to antipodal butyrolactones, overview Pseudomonas fluorescens ACB ?
-
 ?
1.14.13.84 tricyclo[4.2.1.02,5]nonan-3-one + NADPH + O2
-
 Pseudomonas fluorescens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.84 HAPMO
-
 Pseudomonas fluorescens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.84 FAD
-
 Pseudomonas fluorescens
1.14.13.84 NADPH
-
 Pseudomonas fluorescens