EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.4 | 5'-O-trityl-inosine | i.e. KIN59, IC50: 0.044 mM, noncompetitively inhibits, when thymidine or phosphate is the variable substrate. Suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action | Escherichia coli | |
2.4.2.4 | 5'-O-trityl-inosine | i.e. KIN59, IC50: 0.067 mM, noncompetitively inhibits, when thymidine or phosphate is the variable substrate. Suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action | Homo sapiens | |
2.4.2.4 | KIN56 | IC50: 0.232 mM | Escherichia coli | |
2.4.2.4 | KIN56 | IC50: 0.351 mM | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.4 | Escherichia coli | - |
- |
- |
2.4.2.4 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.4 | deoxythymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
2.4.2.4 | deoxythymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
2.4.2.4 | thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
2.4.2.4 | thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.4.2.4 | 0.044 | - |
i.e. KIN59, IC50: 0.044 mM, noncompetitively inhibits, when thymidine or phosphate is the variable substrate. Suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action | Escherichia coli | 5'-O-trityl-inosine | |
2.4.2.4 | 0.067 | - |
i.e. KIN59, IC50: 0.067 mM, noncompetitively inhibits, when thymidine or phosphate is the variable substrate. Suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action | Homo sapiens | 5'-O-trityl-inosine | |
2.4.2.4 | 0.232 | - |
IC50: 0.232 mM | Escherichia coli | KIN56 | |
2.4.2.4 | 0.351 | - |
IC50: 0.351 mM | Homo sapiens | KIN56 |