Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Schilling, S.; Niestroj, A.J.; Rahfeld, J.U.; Hoffmann, T.; Wermann, M.; Zunkel, K.; Wasternack, C.; Demuth, H.U.
    Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators (2003), J. Biol. Chem., 278, 49773-49779.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.5 1,10-phenanthroline inactivated enzyme can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA, little reactivation by Co2+ and Mn2+ Homo sapiens
2.3.2.5 1,4-bis-(imidazol-1-yl)methyl-2,5-dimethylbenzene
-
 Homo sapiens
2.3.2.5 1-(2-oxo-2-phenylethyl)-imidazole
-
 Homo sapiens
2.3.2.5 1-(3-aminopropyl)-imidazole
-
 Homo sapiens
2.3.2.5 1-(6-phenoxyhexyl)-1H-imidazole
-
 Homo sapiens
2.3.2.5 1-Benzylimidazole
-
 Homo sapiens
2.3.2.5 1-methyl-4-(beta-aminoethyl)-imidazole
-
 Homo sapiens
2.3.2.5 1-methyl-5-(beta-aminoethyl)-imidazole
-
 Homo sapiens
2.3.2.5 1-Methylimidazole
-
 Homo sapiens
2.3.2.5 1-vinylimidazole
-
 Homo sapiens
2.3.2.5 2-aminobenzimidazole
-
 Homo sapiens
2.3.2.5 2-ethyl-4-methyl-imidazole
-
 Homo sapiens
2.3.2.5 2-methyl-benzylimidazole
-
 Homo sapiens
2.3.2.5 3-[3-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one
-
 Homo sapiens
2.3.2.5 4-(2-imidazol-1-yl-ethoxy)-benzoic acid
-
 Homo sapiens
2.3.2.5 4-imidazole-carboxaldehyde
-
 Homo sapiens
2.3.2.5 5-amino-3H-imidazole-4-carboxylic acid amide
-
 Homo sapiens
2.3.2.5 5-hydroxymethyl-4-methyl-imidazole
-
 Homo sapiens
2.3.2.5 benzimidazole
-
 Homo sapiens
2.3.2.5 dipicolinic acid inactivated enzyme can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA, little reactivation by Co2+ and Mn2+ Homo sapiens
2.3.2.5 H-His-Trp-OH
-
 Homo sapiens
2.3.2.5 imidazol-4-carbonic acid methylester
-
 Homo sapiens
2.3.2.5 imidazole
-
 Homo sapiens
2.3.2.5 L-histamine
-
 Homo sapiens
2.3.2.5 L-histidinamide
-
 Homo sapiens
2.3.2.5 L-histidine
-
 Homo sapiens
2.3.2.5 L-histidinol
-
 Homo sapiens
2.3.2.5 N-(4-chlorophenyl)-N'-[2-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one
-
 Homo sapiens
2.3.2.5 N-(trimethylsilyl)-imidazole
-
 Homo sapiens
2.3.2.5 N-Acetylimidazole
-
 Homo sapiens
2.3.2.5 N-benzoylimidazole
-
 Homo sapiens
2.3.2.5 N-omega-acetylhistamine
-
 Homo sapiens
2.3.2.5 oxalic acid diimidazolidide
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.5 Co2+ enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+ Homo sapiens
2.3.2.5 Mn2+ enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+ Homo sapiens
2.3.2.5 Zn2+ enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be fully restored by addition of Zn2+ in the presence of equimolar concentrations of EDTA Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Homo sapiens Q16769
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 Gln-7-amido-4-methylcoumarin
-
 Homo sapiens pyroglutamic acid-7-amido-4-methylcoumarin + NH3
-
 ?
2.3.2.5 Gln-Gln
-
 Homo sapiens pyroglutamic acid-Gln + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.5 glutaminyl cyclase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.5 0.0012
-
 N-(4-chlorophenyl)-N'-[2-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.0023
-
 4-(2-imidazol-1-yl-ethoxy)-benzoic acid 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.0062
-
 1-(6-phenoxyhexyl)-1H-imidazole
-
 Homo sapiens
2.3.2.5 0.0071
-
 1-Benzylimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.017
-
 N-omega-acetylhistamine 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.03
-
 1-Methylimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.049
-
 1-vinylimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.078
-
 oxalic acid diimidazolidide 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.103
-
 imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.107
-
 N-Acetylimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.12
-
 1-methyl-5-(beta-aminoethyl)-imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.129
-
 5-hydroxymethyl-4-methyl-imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.138
-
 benzimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.165
-
 2-methyl-benzylimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.167
-
 N-(trimethylsilyl)-imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.174
-
 N-benzoylimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.184
-
 1-(2-oxo-2-phenylethyl)-imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.295
-
 1,4-bis-(imidazol-1-yl)methyl-2,5-dimethylbenzene 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.41
-
 1-(3-aminopropyl)-imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.56
-
 L-histidinamide 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.58
-
 2-ethyl-4-methyl-imidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.6
-
 H-His-Trp-OH 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.818
-
 3-[3-(1H-imidazol-1-yl)propyl]-2-thioxoimidazolidin-4-one 30°C, pH 8.0 Homo sapiens
2.3.2.5 0.85
-
 L-histamine 30°C, pH 8.0 Homo sapiens
2.3.2.5 1.53
-
 L-histidinol 30°C, pH 8.0 Homo sapiens
2.3.2.5 1.8
-
 2-aminobenzimidazole 30°C, pH 8.0 Homo sapiens
2.3.2.5 4.4
-
 L-histidine 30°C, pH 8.0 Homo sapiens
2.3.2.5 7.6
-
 4-imidazole-carboxaldehyde 30°C, pH 8.0 Homo sapiens
2.3.2.5 14.5
-
 imidazol-4-carbonic acid methylester 30°C, pH 8.0 Homo sapiens
2.3.2.5 15.5
-
 5-amino-3H-imidazole-4-carboxylic acid amide 30°C, pH 8.0 Homo sapiens