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Literature summary extracted from

  • Iwamura, K.; Furukawa, K.; Uchikawa, M.; Sojka, B.N.; Kojima, Y.; Wiels, J.; Shiku, H.; Urano, T.; Furukawa, K.
    The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene: a clue to the solution of the P1/P2/p puzzle (2003), J. Biol. Chem., 278, 44429-44438.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.228 DNA sequence determination and analysis, functional expression in L-VTR1 cells, the recombinant cells produce high levels of P1 antigen in the cytoplasm with a small amount on the cell surface, expression as fusion protein with protein A secreted to the cell culture medium Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.228 cytoplasm
-
 Homo sapiens 5737
-
2.4.1.228 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.228 UDP-galactose + beta-D-galactosyl-(1,4)-D-glucosylceramide Homo sapiens
-
 UDP + alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide
-
 ?
2.4.1.228 UDP-galactose + beta-D-galactosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-alpha-D-galactosyl-(1,4)-beta-D-glucosylceramide Homo sapiens P1 antigen synthesis UDP + alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-alpha-D-galactosyl-(1,4)-beta-D-glucosylceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.228 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.228 erythrocyte lower enzyme level in P2-type erythrocytes, high enzyme level in P1-type erythrocytes, no enzyme activity in p-erythrocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.228 additional information substrate specificity Homo sapiens ?
-
 ?
2.4.1.228 UDP-galactose + beta-D-galactosyl-(1,4)-D-glucosylceramide
-
 Homo sapiens UDP + alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide
-
 ?
2.4.1.228 UDP-galactose + beta-D-galactosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-alpha-D-galactosyl-(1,4)-beta-D-glucosylceramide P1 antigen synthesis Homo sapiens UDP + alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-alpha-D-galactosyl-(1,4)-beta-D-glucosylceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.228 alpha1,4Gal-T
-
 Homo sapiens
2.4.1.228 blood group P1 synthase
-
 Homo sapiens
2.4.1.228 Gb3/CD77 synthase
-
 Homo sapiens