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Literature summary extracted from

  • Tsuchida, A.; Okajima, T.; Furukawa, K.; Ando, T.; Ishida, H.; Yoshida, A.; Nakamura, Y.; Kannagi, R.; Kiso, M.
    Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides (2003), J. Biol. Chem., 278, 22787-22794.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.7 0.33
-
GM1b isoform ST6GalNAc VI, pH 6.0, 37°C Homo sapiens
2.4.3.7 0.46
-
sialyl lactoetraosylceramide isoform ST6GalNAc VI, pH 6.0, 37°C Homo sapiens
2.4.3.7 0.56
-
GM1b isoform ST6GalNAc V, pH 6.0, 37°C Homo sapiens
2.4.3.7 0.9
-
sialyl lactoetraosylceramide isoform ST6GalNAc V, pH 6.0, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.7 additional information Homo sapiens enzyme is responsible for synthesis of disialyl Lewis a structures in colon tissues, but not for synthesis of alpha-series gangliosides, model of pathway for synthesis of disialyl lactoetraosylceramides and disialyl Lewis a structures ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.7 Homo sapiens
-
isoforms ST6GalNAc VI and ST6GalNAc V, recombinant enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.7 CMP-N-acetylneuraminate + GM1b
-
Homo sapiens CMP + ?
-
?
2.4.3.7 CMP-N-acetylneuraminate + sialyl lactoetraosylceramide
-
Homo sapiens CMP + ? product are disialyl Lewis a structures ?
2.4.3.7 additional information enzyme is responsible for synthesis of disialyl Lewis a structures in colon tissues, but not for synthesis of alpha-series gangliosides, model of pathway for synthesis of disialyl lactoetraosylceramides and disialyl Lewis a structures Homo sapiens ?
-
?