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Literature summary extracted from

  • de Carvalho, L.P.S.; Argyrou, A.; Blanchard, J.S.
    Slow-onset feedback inhibition: Inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine (2005), J. Am. Chem. Soc., 127, 10004-10005.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.13 L-leucine linear, non-competitive feedback inhibition Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.13 acetyl-CoA + alpha-ketoisovalerate + H2O Mycobacterium tuberculosis first step of leucine biosynthesis alpha-isopropylmalate + CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.13 Mycobacterium tuberculosis
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.13 acetyl-CoA + alpha-ketoisovalerate + H2O first step of leucine biosynthesis Mycobacterium tuberculosis alpha-isopropylmalate + CoA
-
?
2.3.3.13 acetyl-CoA + alpha-ketoisovalerate + H2O aldol condensation reaction Mycobacterium tuberculosis alpha-isopropylmalate + CoA
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.3.13 0.017
-
L-leucine
-
Mycobacterium tuberculosis