Literature summary extracted from

Jeon, J.H.; Lee, H.J.; Jang, G.Y.; Kim, C.W.; Shim, D.M.; Cho, S.Y.; Yeo, E.J.; Park, S.C.; Kim, I.G.
Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine (2004), Exp. Mol. Med., 36, 576-581.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.3.2.13	dithiothreitol	3.8fold increase in activity at 10 mM	Homo sapiens
2.3.2.13	glutathione	reduced, 2.7fold increase in activity at 5 mM	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.2.13	cystamine	50% inhibition at 0.022 mM	Homo sapiens
2.3.2.13	cysteamine	50% inhibition at 0.178 mM	Homo sapiens
2.3.2.13	additional information	inhibitory activity in decreasing order: cystamine, spermidine, spermine, putrescine, cysteamine	Homo sapiens
2.3.2.13	putrescine	-	Homo sapiens
2.3.2.13	spermidine	-	Homo sapiens
2.3.2.13	spermine	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.13	Homo sapiens	-	expression in baculovirus system	-

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Release 2023.1 (January 2023)