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Literature summary extracted from

  • Gutierrez, A.; Munro, A.W.; Grunau, A.; Wolf, C.R.; Scrutton, N.S.; Roberts, G.C.
    Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues (2003), Eur. J. Biochem., 270, 2612-2621.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.2.4 2',5'-ADP increases internal electron transfer in dithionite reduced enzyme Homo sapiens
1.6.2.4 2'-AMP increases internal electron transfer in dithionite reduced enzyme Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.2.4 truncated form lacking the membrane anchoring domain expresed in Escherichia coli BL21(DE3)pLysS Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 2',5'-ADP competitive with NADPH Homo sapiens
1.6.2.4 2'-AMP
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.2.4 2 ferricytochrome P450 + NADPH Homo sapiens involved in drug metabolism 2 ferrocytochrome P450 + NADP+ + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.2.4 recombinant enzyme Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.4 fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 2 ferricytochrome c + NADH low rate of internal electron transfer Homo sapiens 2 ferrocytochrome c + NAD+ + H+
-
?
1.6.2.4 2 ferricytochrome c + NADPH
-
Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
?
1.6.2.4 2 ferricytochrome P450 + NADPH involved in drug metabolism Homo sapiens 2 ferrocytochrome P450 + NADP+ + H+
-
?
1.6.2.4 ferricytochrome c + dithionite very low rate of internal electron transfer Homo sapiens ferrocytochrome c + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.4 NADPH-cytochrome P450 reductase
-
Homo sapiens
1.6.2.4 NADPH-ferrihemoprotein reductase
-
Homo sapiens
1.6.2.4 NADPH:ferrihemoprotein oxidoreductase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 FAD together with FMN Homo sapiens
1.6.2.4 FMN together with FAD Homo sapiens
1.6.2.4 NADPH
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.2.4 0.0054
-
2',5'-ADP pH 7.0, 25°C Homo sapiens
1.6.2.4 0.18
-
2'-AMP pH 7.0, 25°C Homo sapiens