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Literature summary extracted from

  • Hoegberg, P.; Schmidt, C.K.; Nau, H.; Catharine Ross, A.; Zolfaghari, R.; Fletcher, N.; Trossvik, C.; Nilsson, C.B.; Hakansson, H.
    2,3,7,8-Tetrachlorodibenzo-p-dioxin induces lecithin: retinol acyltransferase transcription in the rat kidney (2003), Chem. Biol. Interact., 145, 1-16.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.135 additional information the pollutant 2,3,7,8-tetrachlorodibenzo-4-dioxin, i.e. TCDD, induces enzyme expression in the kidney, induction mechanism, the expression of the cellular retinol binding protein I is unaffected, TCDD alters the retinoid metabolism regulation, expression and activity of cytochrome P450 A1 increases retinoic acid levels in kidney and liver, and enhances enzyme expression in the kidney Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 additional information Rattus norvegicus retinoids play an essential role in development and throughout life, levels in rat tissue after treatment with 2,3,7,8-tetrachlorodibenzo-4-dioxin, overview ?
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] Rattus norvegicus enzyme and cellular retinol binding protein I, CRBP I are involved in retinoid storage regulation, retinoid biosynthetic pathway, overview 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] the retinyl ester is the storage form of retinoids, retinol is the precursor for retinal, which has a function as visual chromophore, and subsequently of retinoic acid, which is a signaling hormone r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 kidney
-
 Rattus norvegicus
-
2.3.1.135 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 additional information retinoids play an essential role in development and throughout life, levels in rat tissue after treatment with 2,3,7,8-tetrachlorodibenzo-4-dioxin, overview Rattus norvegicus ?
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein]
-
 Rattus norvegicus 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
 r
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] enzyme and cellular retinol binding protein I, CRBP I are involved in retinoid storage regulation, retinoid biosynthetic pathway, overview Rattus norvegicus 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein] the retinyl ester is the storage form of retinoids, retinol is the precursor for retinal, which has a function as visual chromophore, and subsequently of retinoic acid, which is a signaling hormone r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin: retinol acyltransferase
-
 Rattus norvegicus
2.3.1.135 LRAT
-
 Rattus norvegicus