Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Akiyama, S.; Furukawa, T.; Sumizawa, T.; Takebayashi, Y.; Nakajima, Y.; Shimaoka, S.; Haraguchi, M.
    The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression (2004), Cancer Sci., 95, 851-857.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.2.4 medicine tumor-associated macrophages that express thymidine phosphorylase may be a good target for chermotherapy of thymidine phosphorylase positive solid tumors Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.4 enzyme complexed with TPI Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 5'-O-tritylinosine
-
 Homo sapiens
2.4.2.4 5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride
-
 Homo sapiens
2.4.2.4 7-deazaxanthine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymidine + phosphate Homo sapiens the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 gliostatin
-
 Homo sapiens
2.4.2.4 PD-ECGF
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.4 0.000002
-
 5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride
-
 Homo sapiens