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Literature summary extracted from

  • Galan, M.C.; Dodson, C.S.; Venot, A.P.; Boons, G.J.
    Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substrates (2004), Bioorg. Med. Chem. Lett., 14, 2205-2208.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.152 0.075
-
 methyl beta-D-2-O-methylgalactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose
-
 Homo sapiens
2.4.1.152 0.115
-
 methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-methylsulfonylamino-beta-D-glucopyranose
-
 Homo sapiens
2.4.1.152 0.12
-
 methyl beta-D-2-O-methylgalactosyl-(1-4)-6-O-methyl-N-acetyl-beta-D-glucosamine
-
 Homo sapiens
2.4.1.152 0.14
-
 methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose
-
 Homo sapiens
2.4.1.152 0.19
-
 methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-acetylamino-beta-D-glucopyranose
-
 Homo sapiens
2.4.1.152 0.25
-
 methyl beta-D-galactosyl-(1-4)-6-O-methylsulfonyl-N-acetyl-beta-D-glucosamine
-
 Homo sapiens
2.4.1.152 0.29
-
 methyl beta-D-galactosyl-(1-4)-6-O-methyl-N-acetyl-beta-D-glucosamine
-
 Homo sapiens
2.4.1.152 0.35
-
 Galbeta(1,3)GlcNAcOMe
-
 Homo sapiens
2.4.1.152 0.39
-
 methyl beta-D-2-O-methylgalactosyl-(1-4)-N-acetyl-beta-D-glucosamine
-
 Homo sapiens
2.4.1.152 0.4
-
 methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-amino-beta-D-glucopyranose
-
 Homo sapiens
2.4.1.152 0.45
-
 methyl beta-D-galactosyl-(1->4)-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl ester
-
 Homo sapiens
2.4.1.152 1.54
-
 methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl amide
-
 Homo sapiens
2.4.3.1 0.7
-
 Methanesulfonic acid (2R,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester
-
 Rattus norvegicus
2.4.3.1 0.8
-
 N-[(2R,3R,4R,5S,6R)-4-Hydroxy-6-(methanesulfonylamino-methyl)-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
-
 Rattus norvegicus
2.4.3.1 1.1
-
 (2S,3S,4R,5R,6R)-5-Acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
-
 Rattus norvegicus
2.4.3.1 1.4
-
 N-[(2R,3R,4R,5S,6R)-6-(Acetylamino-methyl)-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
-
 Rattus norvegicus
2.4.3.1 1.7
-
 Galbeta(1-3)GlcNAcbeta-O-Me
-
 Rattus norvegicus
2.4.3.1 2.4
-
 (2S,3S,4R,5R,6R)-5-Acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methylamide
-
 Rattus norvegicus
2.4.3.1 3.1
-
 N-[(2R,3R,4R,5S,6R)-5-((2S,3R,4S,5R,6R)-4,5-Dihydroxy-6-hydroxymethyl-3-methoxy-tetrahydro-pyran-2-yloxy)-6-formylaminomethyl-4-hydroxy-2-methoxy-tetrahydro-pyran-3-yl]-acetamide
-
 Rattus norvegicus
2.4.3.1 4.1
-
 (Gal-3-O-Me)beta(1-3)GlcNAcbeta-O-Me
-
 Rattus norvegicus
2.4.3.1 4.3
-
 Galbeta(1-3)(GlcNAc-6-O-Me)beta-O-Me
-
 Rattus norvegicus
2.4.3.1 5.8
-
 N-[(2R,3R,4R,5S,6R)-6-Aminomethyl-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
-
 Rattus norvegicus
2.4.3.1 11.2
-
 (Gal-3-O-Me)beta(1-3)(GlcNAc-6-O-Me)beta-O-Me
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.152 Homo sapiens
-
 recombinant enzyme
-
2.4.3.1 Rattus norvegicus
-
 recombinant enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.152 GDP-fucose + Galbeta(1,3)GlcNAcOMe
-
 Homo sapiens GDP + Galbeta(1,4)(Fucalpha(1,3))GlcNAcOMe
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-2-O-methylgalactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose
-
 Homo sapiens GDP + methyl beta-D-2-O-methylgalactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-2-O-methylgalactosyl-(1-4)-6-O-methyl-N-acetyl-beta-D-glucosamine
-
 Homo sapiens GDP + methyl beta-D-2-O-methylgalactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-6-O-methyl-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-2-O-methylgalactosyl-(1-4)-N-acetyl-beta-D-glucosamine
-
 Homo sapiens GDP + methyl beta-D-2-O-methylgalactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-acetylamino-beta-D-glucopyranose
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-acetylamino-beta-D-glucopyranose
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-amino-beta-D-glucopyranose
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-amino-beta-D-glucopyranose
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-methylsulfonylamino-beta-D-glucopyranose
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-methylsulfonylamino-beta-D-glucopyranose
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl amide
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl amide
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl ester
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl ester
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-6-O-methyl-N-acetyl-beta-D-glucosamine
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-6-O-methyl-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.152 GDP-fucose + methyl beta-D-galactosyl-(1-4)-6-O-methylsulfonyl-N-acetyl-beta-D-glucosamine
-
 Homo sapiens GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-6-O-methylsulfonyl-N-acetyl-beta-D-glucosamine
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
-
 Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 160% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methylamide 0.2% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)(GlcNAc-6-O-Me)beta-O-Me 50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)GlcNAcbeta-O-Me 80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + Galbeta(1-3)(GlcNAc-6-O-Me)beta-O-Me 80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + Galbeta(1-3)GlcNAcbeta-O-Me
-
 Rattus norvegicus CMP + NeuAcalpha(2-6)Galbeta(1-3)GlcNAcbeta-O-Me
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + methanesulfonic acid (2R,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester 90% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-4-hydroxy-6-(methanesulfonylamino-methyl)-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide 70% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-5-((2S,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-methoxy-tetrahydro-pyran-2-yloxy)-6-formylaminomethyl-4-hydroxy-2-methoxy-tetrahydro-pyran-3-yl]-acetamide as active as Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-(acetylamino-methyl)-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide 60% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-aminomethyl-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide 50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me Rattus norvegicus CMP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.152 alpha-1,3-fucosyltransferase VI
-
 Homo sapiens
2.4.3.1 alpha-2,6-sialyltransferase
-
 Rattus norvegicus