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Literature summary extracted from

  • Wang, H.; Vath, G.M.; Gleason, K.J.; Hanna, P.E.; Wagner, C.R.
    Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies (2004), Biochemistry, 43, 8234-8246.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 bromoacetamide NAT2 Mesocricetus auratus
2.3.1.5 iodoacetamide Cys68 is the only site of alkylation, NAT2 Mesocricetus auratus
2.3.1.5 additional information no significant inactivation with either iodoacetic acid or bromoacetic acid, NAT2 Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Mesocricetus auratus
-
 enzyme form NAT2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.5
-
 Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid the catalytic mechanism depends on the formation of a thiolate-imidazolium ion pair (Cys-S-)-(His-ImH+) Mesocricetus auratus CoA + 4-acetylaminobenzoic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 NAT2
-
 Mesocricetus auratus