Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Agrawal, N.; Lesley, S.A.; Kuhn, P.; Kohen, A.
    Mechanistic studies of a flavin-dependent thymidylate synthase (2004), Biochemistry, 43, 10295-10301.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.148 medicine the unique mechanism of FDTS makes it an attractive target for antibiotic drug development Thermotoga maritima

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.148 NADPH
-
 Thermotoga maritima

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.148 additional information Thermotoga maritima the enzyme is essential to DNA replication ?
-
 ?
2.1.1.148 additional information Thermotoga maritima DSM 3109 the enzyme is essential to DNA replication ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.148 Thermotoga maritima Q9WYT0 TM0449
-
2.1.1.148 Thermotoga maritima DSM 3109 Q9WYT0 TM0449
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.148 additional information the enzyme is essential to DNA replication Thermotoga maritima ?
-
 ?
2.1.1.148 additional information the enzyme is essential to DNA replication Thermotoga maritima DSM 3109 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.148 FDTS
-
 Thermotoga maritima
2.1.1.148 flavin-dependent TS
-
 Thermotoga maritima

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.148 FAD the pro-R hydride of NADPH and not the R6 hydride of the tetrahydropterin is the reducing agent. The stereospecificity for the pro-R NADPH oxidation is not absolute. The hydride is transferred to FAD, which is the rate-limiting step of the catalytic cascade Thermotoga maritima
2.1.1.148 NADPH the pro-R hydride of NADPH and not the R6 hydride of the tetrahydropterin is the reducing agent. The stereospecificity for the pro-R NADPH oxidation is not absolute. The hydride is transferred to FAD, which is the rate-limiting step of the catalytic cascade Thermotoga maritima