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Literature summary extracted from

  • Draker, K.A.; Northrop, D.B.; Wright, G.D.
    Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity (2003), Biochemistry, 42, 6565-6574.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.82 additional information Enterococcus faecium the enzyme is an important microbial resistance determinant ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Enterococcus faecium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + kanamycin A
-
Enterococcus faecium CoA + N6'-acetylkanamycin A
-
?
2.3.1.82 acetyl-CoA + neamine
-
Enterococcus faecium CoA + N6'-acetylneamine
-
?
2.3.1.82 acetyl-CoA + neomycin C
-
Enterococcus faecium CoA + N6'-acetylneomycin
-
?
2.3.1.82 acetyl-CoA + ribostamycin
-
Enterococcus faecium CoA + N6'acetylribostamycin
-
?
2.3.1.82 additional information the enzyme is an important microbial resistance determinant Enterococcus faecium ?
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.82 dimer
-
Enterococcus faecium

Synonyms

EC Number Synonyms Comment Organism
2.3.1.82 AAC(6')-Ii
-
Enterococcus faecium
2.3.1.82 aminoglycoside 6'-N-acetyltransferase
-
Enterococcus faecium

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.82 0.046
-
ribostamycin pH 6.0, 37°C, mutant enzyme W164A Enterococcus faecium
2.3.1.82 0.048
-
neamine pH 6.0, 37°C, mutant enzyme W164A Enterococcus faecium
2.3.1.82 0.08
-
kanamycin A pH 6.0, 37°C, mutant enzyme W164A Enterococcus faecium
2.3.1.82 0.135
-
neomycin C pH 6.0, 37°C, mutant enzyme W164A Enterococcus faecium
2.3.1.82 0.173
-
acetyl-CoA pH 6.0, 37°C, mutant enzyme W164A Enterococcus faecium
2.3.1.82 0.205
-
neomycin C pH 6.0, 37°C, wild-type enzyme Enterococcus faecium
2.3.1.82 0.338
-
ribostamycin pH 6.0, 37°C, wild-type enzyme Enterococcus faecium
2.3.1.82 0.403
-
acetyl-CoA pH 6.0, 37°C, wild-type enzyme Enterococcus faecium
2.3.1.82 0.419
-
neamine pH 6.0, 37°C, wild-type enzyme Enterococcus faecium
2.3.1.82 0.816
-
kanamycin A pH 6.0, 37°C, wild-type enzyme Enterococcus faecium