Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tomson, F.L.; Morgan, J.E.; Gu, G.; Barquera, B.; Vygodina, T.V.; Gennis, R.B.
    Substitutions for glutamate 101 in subunit II of cytochrome c oxidase from Rhodobacter sphaeroides result in blocking the proton-conducting K-channel (2003), Biochemistry, 42, 1711-1717.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
7.1.1.9 E101A mutation in subunit II strongly reduces oxidase activity to 8% Cereibacter sphaeroides
7.1.1.9 E101C mutation in subunit II strongly reduces oxidase activity to 8% Cereibacter sphaeroides
7.1.1.9 E101D mutation in subunit II strongly reduces oxidase activity to 16% Cereibacter sphaeroides
7.1.1.9 E101H mutation in subunit II strongly reduces oxidase activity to 19% Cereibacter sphaeroides
7.1.1.9 E101I mutation in subunit II strongly reduces oxidase activity to 8% Cereibacter sphaeroides
7.1.1.9 E101N mutation in subunit II strongly reduces oxidase activity to 17% Cereibacter sphaeroides
7.1.1.9 E101Q mutation in subunit II strongly reduces oxidase activity to 14% Cereibacter sphaeroides
7.1.1.9 H300A mutation in subunit I increases oxidase activity to 111% Cereibacter sphaeroides
7.1.1.9 K362M enzyme with mutation in subunit I is inactive Cereibacter sphaeroides
7.1.1.9 L100AV mutation in subunit II increases oxidase turnover to 45% Cereibacter sphaeroides
7.1.1.9 S299A mutation in subunit I reduces oxidase activity to 45% Cereibacter sphaeroides
7.1.1.9 W104V mutation in subunit II reduces oxidase activity to 45% Cereibacter sphaeroides
7.1.1.9 W105A mutation in subunit II reduces oxidase activity to 50% Cereibacter sphaeroides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.9 additional information Cereibacter sphaeroides the predominant entry point for protons going into the K-channel of cytochrome oxidase is the surface-exposed glutamic acid E101 in subunit II ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Cereibacter sphaeroides
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2
-
 Cereibacter sphaeroides ferricytochrome c + H2O
-
 ?
7.1.1.9 additional information the predominant entry point for protons going into the K-channel of cytochrome oxidase is the surface-exposed glutamic acid E101 in subunit II Cereibacter sphaeroides ?
-
 ?