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Literature summary extracted from

  • Vella, F.; Ferry, G.; Delagrange, P.; Boutin, J.A.
    NRH:quinone reductase 2: an enzyme of surprises and mysteries (2005), Biochem. Pharmacol., 71, 1-12.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.10.5.1 2.1 A resolution Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.2 NAD(P)H + H+ + a quinone Homo sapiens the enzyme catalyzes a detoxification process. QR1 gene expression is induced in response to xenobiotics, oxidants, heavy metals, UV light, and ionisation radiation. The enzyme is part of an electrophilic-induced and/or oxidative stress-induced cellular defense mechanism that includes the induction of more than two dozen defensive genes NAD(P)+ + a hydroquinone
-
 ?
1.10.5.1 additional information Mus musculus by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis ?
-
 ?
1.10.5.1 additional information Homo sapiens high QR2 activity might make individuals more susceptible to Parkinson‘s disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens P15559 comparison with quinone reductase 2
-
1.10.5.1 Homo sapiens P16083 comparison with quinone reductase 1
-
1.10.5.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 liver traces Homo sapiens
-
1.6.5.2 additional information no expression in erythrocytes Homo sapiens
-
1.10.5.1 brain minimal expression Homo sapiens
-
1.10.5.1 erythrocyte modest level Homo sapiens
-
1.10.5.1 heart
-
 Homo sapiens
-
1.10.5.1 kidney
-
 Homo sapiens
-
1.10.5.1 liver
-
 Homo sapiens
-
1.10.5.1 liver high expression level Homo sapiens
-
1.10.5.1 additional information no expression in placenta Homo sapiens
-
1.10.5.1 additional information no expression in skeletal muscle Mus musculus
-
1.10.5.1 pancreas minimal expression Homo sapiens
-
1.10.5.1 skeletal muscle high expression level Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 NAD(P)H + H+ + a quinone the enzyme catalyzes a detoxification process. QR1 gene expression is induced in response to xenobiotics, oxidants, heavy metals, UV light, and ionisation radiation. The enzyme is part of an electrophilic-induced and/or oxidative stress-induced cellular defense mechanism that includes the induction of more than two dozen defensive genes Homo sapiens NAD(P)+ + a hydroquinone
-
 ?
1.10.5.1 additional information by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis Mus musculus ?
-
 ?
1.10.5.1 additional information high QR2 activity might make individuals more susceptible to Parkinson‘s disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite Homo sapiens ?
-
 ?
1.10.5.1 additional information enzyme cannot use NADH or NADPH as reducing agent Homo sapiens ?
-
 ?
1.10.5.1 N-benzyldihydronicotinamide + menadione
-
 Mus musculus ?
-
 ?
1.10.5.1 N-methyldihydronicotinamide + menadione
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NRH:quinone reductase 1
-
 Homo sapiens
1.6.5.2 QR1
-
 Homo sapiens
1.6.5.2 quinone reductase 1
-
 Homo sapiens
1.10.5.1 NRH:quinone reductase 2
-
 Mus musculus
1.10.5.1 NRH:quinone reductase 2
-
 Homo sapiens
1.10.5.1 QR2
-
 Mus musculus
1.10.5.1 QR2
-
 Homo sapiens
1.10.5.1 quinone reductase 2
-
 Mus musculus
1.10.5.1 quinone reductase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 NAD(P)H Gly149, Tyr155 and His161 are directly involved in the electron transfer from NAD(P)H to FAD and from FADH2 to the quinone Homo sapiens
1.10.5.1 FAD contains 1 FAD per monomer firmly bound to the enzyme through multiple interactions Homo sapiens
1.10.5.1 additional information enzyme cannot use NADH or NADPH as reducing agent Homo sapiens