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Literature summary extracted from
- Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney (2004), Biochem. Biophys. Res. Commun., 324, 1386-1392.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.13.99.1 | expression in Escherichia coli | Mus musculus |
| 1.13.99.1 | expression in Escherichia coli | Rattus norvegicus |
| 1.13.99.1 | expression in Escherichia coli | Homo sapiens |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.13.99.1 | after storage at 4°C for few weeks, a specific truncation due to degradation is observed, extended storage also causes the accumulation of a small proportion of apparantly dimerized MIOX | Mus musculus |
| 1.13.99.1 | after storage at 4°C for few weeks, a specific truncation due to degradation is observed, extended storage also causes the accumulation of a small proportion of apparantly dimerized MIOX | Rattus norvegicus |
| 1.13.99.1 | after storage at 4°C for few weeks, a specific truncation due to degradation is observed, extended storage also causes the accumulation of a small proportion of apparantly dimerized MIOX | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.99.1 | 3.3 | - |
myo-inositol | MIOX activity present in peak 1 of hydrophobic-interaction chromatography on Resource-PHE column | Mus musculus |  |
| 1.13.99.1 | 3.5 | - |
myo-inositol | MIOX activity present in peak 3 of hydrophobic-interaction chromatography on Resource-PHE column | Homo sapiens | |
| 1.13.99.1 | 5.8 | - |
myo-inositol | MIOX activity present in peak 1 of hydrophobic-interaction chromatography on Resource-PHE column | Homo sapiens | |
| 1.13.99.1 | 8.8 | - |
myo-inositol | MIOX activity present in peak 3 of hydrophobic-interaction chromatography on Resource-PHE column | Mus musculus | |
| 1.13.99.1 | 14.6 | - |
myo-inositol | MIOX activity present in peak 2 of hydrophobic-interaction chromatography on Resource-PHE column | Rattus norvegicus | |
| 1.13.99.1 | 24.7 | - |
myo-inositol | MIOX activity present in peak 2 of hydrophobic-interaction chromatography on Resource-PHE column | Mus musculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.13.99.1 | 33000 | - |
1 * 33000, deduced from nucleotide sequence, SDS-PAGE | Mus musculus |
| 1.13.99.1 | 33000 | - |
1 * 33000, deduced from nucleotide sequence, SDS-PAGE | Rattus norvegicus |
| 1.13.99.1 | 33000 | - |
1 * 33000, deduced from nucleotide sequence, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.99.1 | myo-inositol + O2 | Mus musculus | first commited step in myo-inositol catabolism | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | Rattus norvegicus | first commited step in myo-inositol catabolism | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | Homo sapiens | first commited step in myo-inositol catabolism | D-glucuronic acid + H2O | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.99.1 | Homo sapiens | Q9UGB7 | - |
- |
| 1.13.99.1 | Mus musculus | Q9QXN5 | - |
- |
| 1.13.99.1 | Rattus norvegicus | Q9QXN4 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.13.99.1 | recombinant MIOX | Mus musculus |
| 1.13.99.1 | recombinant MIOX | Rattus norvegicus |
| 1.13.99.1 | recombinant MIOX | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.99.1 | kidney | - |
Mus musculus | - |
| 1.13.99.1 | kidney | - |
Rattus norvegicus | - |
| 1.13.99.1 | kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.99.1 | myo-inositol + O2 | - |
Mus musculus | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | - |
Rattus norvegicus | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | - |
Homo sapiens | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | first commited step in myo-inositol catabolism | Mus musculus | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | first commited step in myo-inositol catabolism | Rattus norvegicus | D-glucuronic acid + H2O | - |
ir | |
| 1.13.99.1 | myo-inositol + O2 | first commited step in myo-inositol catabolism | Homo sapiens | D-glucuronic acid + H2O | - |
ir | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.13.99.1 | monomer | 1 * 33000, deduced from nucleotide sequence, SDS-PAGE | Mus musculus |
| 1.13.99.1 | monomer | 1 * 33000, deduced from nucleotide sequence, SDS-PAGE | Rattus norvegicus |
| 1.13.99.1 | monomer | 1 * 33000, deduced from nucleotide sequence, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.99.1 | MIOX | - |
Mus musculus |
| 1.13.99.1 | MIOX | - |
Rattus norvegicus |
| 1.13.99.1 | MIOX | - |
Homo sapiens |
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