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Literature summary extracted from
- Mechanistic differences in inhibition of ubiquinol cytochrome c reductase by the proximal Qo-site inhibitors famoxadone and methoxyacrylate stilbene (2005), Arch. Biochem. Biophys., 435, 280-290.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.8 | Antimycin | - |
Bos taurus |  |
| 7.1.1.8 | famoxadone | reversible, tight-binding, non-competitive inhibitor, proximal Qo-site inhibitor, binding and inhibition mechanism, overview | Bos taurus | |
| 7.1.1.8 | methoxyacrylate stilbene | reversible, tight-binding, mixed-competitive inhibitor, proximal Qo-site inhibitor, binding and inhibition mechanism, overview | Bos taurus | |
| 7.1.1.8 | Stigmatellin | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.1.1.8 | additional information | - |
additional information | steady-state kinetics | Bos taurus | |
| 7.1.1.8 | 0.072 | - |
QH2 | pH 7.2, 25°C | Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.8 | membrane | - |
Bos taurus | 16020 | - |
| 7.1.1.8 | mitochondrion | - |
Bos taurus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.8 | ubiquinol-2 + 2 ferricytochrome c | Bos taurus | - |
ubiquinone-2 + 2 ferrocytochrome c + 2 H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.8 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.1.1.8 | to homogeneity from heart mitochondria | Bos taurus |
Renatured (Commentary)
| EC Number | Renatured (Comment) | Organism |
|---|---|---|
| 7.1.1.8 | reconstitution of the solubilized membrane-protein complex in phospholipid vesicles | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.1.1.8 | heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.8 | decyl-ubiquinol + ferricytochrome c | - |
Bos taurus | decyl-ubiquinone + ferrocytochrome c | - |
? | |
| 7.1.1.8 | ubiquinol-2 + 2 ferricytochrome c | - |
Bos taurus | ubiquinone-2 + 2 ferrocytochrome c + 2 H+ | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.1.1.8 | 25 | - |
assay at | Bos taurus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.1.1.8 | additional information | - |
additional information | inhibition mechanism and kinetics | Bos taurus | |
| 7.1.1.8 | 0.000022 | - |
methoxyacrylate stilbene | pH 7.2, 25°C | Bos taurus | |
| 7.1.1.8 | 0.000195 | - |
famoxadone | pH 7.2, 25°C | Bos taurus | |
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