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Literature summary extracted from

  • Bhushan, B.; Halasz, A.; Spain, J.C.; Hawari, J.
    Initial reaction(s) in biotransformation of CL-20 is catalyzed by salicylate 1-monooxygenase from Pseudomonas sp. strain ATCC 29352 (2004), Appl. Environ. Microbiol., 70, 4040-4047.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.1 O2 inhibits biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.1 Pseudomonas sp.
-
 ATCC 29352
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.1 0.000256
-
 biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane Pseudomonas sp.
1.14.13.1 0.58
-
 reaction with salicylate Pseudomonas sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.1 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane + NADH the enzyme catalyzes two oxygen-sensitive single-electron transfer steps necessary to release two nitrite ions from 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane and this is followed by the secondary decomposition of this energetic chemical Pseudomonas sp. NO2- + N2O + formate + NH4+ N2O is abiotically produced from NO2-NH2 ?
1.14.13.1 salicylate + NADH + H+ + O2
-
 Pseudomonas sp. catechol + NAD+ + H2O + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.1 FAD the FAD-site of the enzyme is involved in the biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane Pseudomonas sp.
1.14.13.1 NADH
-
 Pseudomonas sp.