Literature summary extracted from

Helmick, R.A.; Fletcher, A.E.; Gardner, A.M.; Gessner, C.R.; Hvitved, A.N.; Gustin, M.C.; Gardner, P.R.
Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin (2005), Antimicrob. Agents Chemother., 49, 1837-1843.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.12.17	clotrimazole	-	Candida albicans
1.14.12.17	clotrimazole	-	Escherichia coli
1.14.12.17	clotrimazole	-	Saccharomyces cerevisiae
1.14.12.17	econazole	-	Candida albicans
1.14.12.17	econazole	-	Escherichia coli
1.14.12.17	econazole	-	Saccharomyces cerevisiae
1.14.12.17	imidazole	imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism	Candida albicans
1.14.12.17	imidazole	imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism	Escherichia coli
1.14.12.17	imidazole	imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism	Saccharomyces cerevisiae
1.14.12.17	ketoconazole	-	Candida albicans
1.14.12.17	ketoconazole	-	Escherichia coli
1.14.12.17	ketoconazole	-	Saccharomyces cerevisiae
1.14.12.17	miconazole	competitive with respect to O2 and NO	Candida albicans
1.14.12.17	miconazole	competitive with respect to O2 and NO	Escherichia coli
1.14.12.17	miconazole	competitive with respect to O2 and NO	Saccharomyces cerevisiae
1.14.12.17	NO	high concentrations, competition with O2, augmented by miconazole	Candida albicans
1.14.12.17	NO	high concentrations, competition with O2, augmented by miconazole	Escherichia coli
1.14.12.17	NO	high concentrations, competition with O2, augmented by miconazole	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.12.17	Candida albicans	-	-	-
1.14.12.17	Escherichia coli	-	-	-
1.14.12.17	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.12.17	NO + O2 + NADH	-	Escherichia coli	NO3- + NAD+	-	?
1.14.12.17	NO + O2 + NADH	-	Saccharomyces cerevisiae	NO3- + NAD+	-	?
1.14.12.17	NO + O2 + NADH	-	Candida albicans	NO3- + NAD+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.12.17	flavohemoglobin	-	Escherichia coli
1.14.12.17	flavohemoglobin	-	Saccharomyces cerevisiae
1.14.12.17	flavohemoglobin	-	Candida albicans
1.14.12.17	NOD	-	Escherichia coli
1.14.12.17	NOD	-	Saccharomyces cerevisiae
1.14.12.17	NOD	-	Candida albicans

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.12.17	NADH	-	Escherichia coli
1.14.12.17	NADH	-	Saccharomyces cerevisiae
1.14.12.17	NADH	-	Candida albicans

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.14.12.17	0.00008	-	miconazole	-	Escherichia coli
1.14.12.17	0.000225	-	econazole	-	Candida albicans
1.14.12.17	0.00055	-	econazole	-	Escherichia coli
1.14.12.17	0.00065	-	clotrimazole	-	Candida albicans
1.14.12.17	0.0007	-	miconazole	-	Candida albicans
1.14.12.17	0.0013	-	clotrimazole	-	Escherichia coli
1.14.12.17	0.005	-	ketoconazole	-	Escherichia coli
1.14.12.17	0.012	-	miconazole	-	Saccharomyces cerevisiae
1.14.12.17	0.0125	-	ketoconazole	-	Candida albicans
1.14.12.17	0.03	-	econazole	-	Saccharomyces cerevisiae
1.14.12.17	0.05	-	clotrimazole	-	Saccharomyces cerevisiae
1.14.12.17	0.1	-	ketoconazole	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)