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Literature summary extracted from

  • Patel, R.N.
    Stereoselective biotransformations in synthesis of some pharmaceutical intermediates (1997), Adv. Appl. Microbiol., 43, 91-140.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.3 synthesis production of [4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one acetate, which is a hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor and a potential anticholesterol drug candidate Burkholderia cepacia

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Burkholderia cepacia
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 (R,S)-[4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one + isopropenyl acetate
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 Burkholderia cepacia (R)-(+)-[4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-hydroxy-2H-pyran-2-one + (S)-(-)-[4-[4a,6b(E)]]-6-[4,4-bis(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)-1,3-butadienyl]-tetrahydro-4-acetyloxy-2H-pyran-2-one + prop-1-en-2-ol
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 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.3 37
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 Burkholderia cepacia