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Literature summary extracted from

  • Szkopinska, A.; Plochocka, D.
    Farnesyl diphosphate synthase; regulation of product specificity (2005), Acta Biochim. Pol., 52, 45-55.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.10 F220A 100000fold decrease in catalytic activity Geobacillus stearothermophilus
2.5.1.10 Q221E 1000fold decrease in catalytic activity Geobacillus stearothermophilus
2.5.1.10 R295V no marked change in catalytic activity Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.10 dimethylallyl diphosphate + isopentenyl diphosphate Geobacillus stearothermophilus key enzyme in isoprenoid biosynthesis diphosphate + geranyl diphosphate
-
 ?
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate Geobacillus stearothermophilus key enzyme in isoprenoid biosynthesis diphosphate + trans,trans-farnesyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.10 Geobacillus stearothermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.10 dimethylallyl diphosphate + isopentenyl diphosphate key enzyme in isoprenoid biosynthesis Geobacillus stearothermophilus diphosphate + geranyl diphosphate
-
 ?
2.5.1.10 dimethylallyl diphosphate + isopentenyl diphosphate the synthase amino-acid residues at the 4th and 5th position before the first aspartate rich motif mainly determine product specificity Geobacillus stearothermophilus diphosphate + geranyl diphosphate
-
 ?
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate key enzyme in isoprenoid biosynthesis Geobacillus stearothermophilus diphosphate + trans,trans-farnesyl diphosphate
-
 ?
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate the synthase amino-acid residues at the 4th and 5th position before the first aspartate rich motif mainly determine product specificity Geobacillus stearothermophilus diphosphate + trans,trans-farnesyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.10 farnesyl diphosphate synthase
-
 Geobacillus stearothermophilus
2.5.1.10 FPPS
-
 Geobacillus stearothermophilus