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Literature summary extracted from

  • Harkiolaki, M.; Dodson, E.J.; Bernier-Villamor, V.; Turkenburg, J.P.; Gonzalez-Pacanowska, D.; Wilson, K.S.
    The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold (2004), Structure, 12, 41-53.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.6.1.23 medicine potential target for treatment of Chagas' disease Trypanosoma cruzi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.23 expressed in Escherichia coli BL21(DE3) Trypanosoma cruzi

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.23 vapor diffusion method Trypanosoma cruzi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.23 Mg2+ required Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Trypanosoma cruzi removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Trypanosoma cruzi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.23 recombinant enzyme Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUDP + H2O
-
 Trypanosoma cruzi dUMP + phosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Trypanosoma cruzi dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Trypanosoma cruzi dUMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.23 dimer two identical subunits, crystal structure analysis Trypanosoma cruzi