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Literature summary extracted from

  • Sperker, B.; Mürdter, T.E.; Schick, M.; Eckhardt, K.; Bosslet, K.; Kroemer, H.K.
    Interindividual variability in expression and activity of human beta-glucuronidase in liver and kidney: consequences for drug metabolism (1997), J. Pharmacol. Exp. Ther., 281, 914-920.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.31 medicine a high varability in the expression of beta-Glc in human liver and kidney. Therefore cleavage of drug glucuronides that accumulate during chronic therapy or are used as prodrugs can show a wide interindividual variability in humans, which might result in variable response to drugs Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.31 estradiol 3-glucuronide
-
 Homo sapiens
3.2.1.31 glycyrrhizin
-
 Homo sapiens
3.2.1.31 paracetamol glucuronide
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.31 1.04
-
 4-methylumbelliferyl-beta-D-glucuronide enzyme from kidney Homo sapiens
3.2.1.31 1.32
-
 4-methylumbelliferyl-beta-D-glucuronide enzyme from liver Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.31 kidney high varability in the expression Homo sapiens
-
3.2.1.31 liver high varability in the expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.31 4-methylumbelliferyl-beta-D-glucuronide + H2O
-
 Homo sapiens 4-methylumbelliferone + D-glucuronic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.31 beta-Gluc
-
 Homo sapiens
3.2.1.31 beta-glucuronidase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.31 0.47
-
 glycyrrhizin enzyme from liver Homo sapiens
3.2.1.31 0.57
-
 glycyrrhizin enzyme from kidney Homo sapiens
3.2.1.31 0.9
-
 estradiol 3-glucuronide enzyme from liver Homo sapiens
3.2.1.31 1.2
-
 estradiol 3-glucuronide enzyme from kidney Homo sapiens
3.2.1.31 1.6
-
 paracetamol glucuronide enzyme from liver Homo sapiens
3.2.1.31 2
-
 paracetamol glucuronide enzyme from kidney Homo sapiens