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Literature summary extracted from

  • Tretter, L.; Adam-Vizi, V.
    Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase (2004), J. Neurosci., 24, 7771-7778.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.2 ADP
-
Sus scrofa
1.2.4.2 NADH stimulates H2O2 production reaction of the enzyme Cavia porcellus
1.2.4.2 NADH stimulates H2O2 production reaction of the enzyme Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.2 H2O2
-
Cavia porcellus
1.2.4.2 H2O2
-
Sus scrofa
1.2.4.2 NAD+ inhibits H2O2 production reaction of the enzyme Cavia porcellus
1.2.4.2 NAD+ inhibits H2O2 production reaction of the enzyme Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.2 mitochondrion
-
Cavia porcellus 5739
-
1.2.4.2 mitochondrion
-
Sus scrofa 5739
-
1.2.4.2 synaptosome
-
Cavia porcellus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.4.2 Ca2+ activates both catalytic function and H2O2 production Cavia porcellus
1.2.4.2 Ca2+ activates both catalytic function and H2O2 production Sus scrofa
1.2.4.2 Mg2+
-
Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Cavia porcellus
-
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Sus scrofa
-
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 additional information Sus scrofa enzyme also catalyzes the production of H2O2 from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a target for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview ?
-
?
1.2.4.2 additional information Cavia porcellus enzyme also catalyzes the production of H2O2 in vivo, in vitro, and in situ from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a atrget for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.2 Cavia porcellus
-
-
-
1.2.4.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.4.2 enzyme is further purified from commercial pig heart preparation Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.2 brain cortex
-
Cavia porcellus
-
1.2.4.2 commercial preparation from heart Sus scrofa
-
1.2.4.2 heart
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.4.2 additional information
-
-
Sus scrofa
1.2.4.2 additional information
-
activity under different conditions in synaptosomes Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.2 2-oxoglutarate + CoA
-
Cavia porcellus ? + H2O2
-
?
1.2.4.2 2-oxoglutarate + CoA
-
Sus scrofa ? + H2O2
-
?
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Cavia porcellus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Sus scrofa [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.4.2 additional information enzyme also catalyzes the production of H2O2 from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a target for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview Sus scrofa ?
-
?
1.2.4.2 additional information enzyme also catalyzes the production of H2O2 in vivo, in vitro, and in situ from 2-oxoglutarate with CoA in absence of NAD+, which inhibits this reaction, enzyme is a atrget for reactive oxygen species and also contributes to generation of oxidative stress in mitochondria when NADH oxidation is impaired, overview Cavia porcellus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.2 alpha-ketoglutarate dehydrogenase
-
Cavia porcellus
1.2.4.2 alpha-ketoglutarate dehydrogenase
-
Sus scrofa
1.2.4.2 alpha-KGDH
-
Cavia porcellus
1.2.4.2 alpha-KGDH
-
Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.4.2 37
-
assay at Sus scrofa
1.2.4.2 37
-
assay at, synaptosomes Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.4.2 7.4
-
assay at Sus scrofa
1.2.4.2 7.4
-
assay at, synaptosomes Cavia porcellus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.2 NAD+
-
Cavia porcellus
1.2.4.2 NAD+
-
Sus scrofa
1.2.4.2 thiamine diphosphate
-
Cavia porcellus
1.2.4.2 thiamine diphosphate
-
Sus scrofa