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Literature summary extracted from

  • Moroz, O.V.; Harkiolaki, M.; Galperin, M.Y.; Vagin, A.A.; Gonzalez-Pacanowska, D.; Wilson, K.S.
    The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases (2004), J. Mol. Biol., 342, 1583-1597.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.6.1.23 medicine potential drug target Campylobacter jejuni

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.23 expressed in Escherichia coli BL21(DE3) Campylobacter jejuni

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.23
-
 Campylobacter jejuni

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.23 Mg2+ required, three ions per subunit Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Campylobacter jejuni removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Campylobacter jejuni
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.23 recombinant protein Campylobacter jejuni

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Campylobacter jejuni dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Campylobacter jejuni dUMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.23 dimer crystal structure analysis Campylobacter jejuni