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Literature summary extracted from

  • Kihara, A.; Igarashi, Y.
    FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane (2004), J. Biol. Chem., 279, 49243-49250.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.102 expression in yeast cells Homo sapiens
1.1.1.102 expression in yeast cells Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.102 0.003
-
3-ketodihydrosphingosine pH 7.5, 37°C Homo sapiens
1.1.1.102 0.028
-
NADPH pH 7.5, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.102 endoplasmic reticulum
-
Homo sapiens 5783
-
1.1.1.102 endoplasmic reticulum
-
Mus musculus 5783
-
1.1.1.102 membrane of endoplasmic reticulum Mus musculus 16020
-
1.1.1.102 membrane of endoplasmic reticulum, the large hydrophilic domain, which contains putative active site residues, faces the cytosol Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.102 Homo sapiens Q06136
-
-
1.1.1.102 Mus musculus Q6GV12
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.102 colon low expression Homo sapiens
-
1.1.1.102 heart high expression Homo sapiens
-
1.1.1.102 heart low level of expression Mus musculus
-
1.1.1.102 kidney high expression Mus musculus
-
1.1.1.102 leukocyte pheripheral blood, low expression Homo sapiens
-
1.1.1.102 lung high expression Mus musculus
-
1.1.1.102 placenta highest expression Mus musculus
-
1.1.1.102 skeletal muscle high expression Homo sapiens
-
1.1.1.102 skeletal muscle low level of expression Mus musculus
-
1.1.1.102 small intestine high expression Mus musculus
-
1.1.1.102 spleen low level of expression Mus musculus
-
1.1.1.102 stomach high expression Mus musculus
-
1.1.1.102 thymus low expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.102 3-ketodihydrosphingosine + NADPH
-
Homo sapiens dihydrosphingosine + NADP+
-
?
1.1.1.102 3-ketodihydrosphingosine + NADPH
-
Mus musculus dihydrosphingosine + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.102 3-ketodihydrosphingosine reductase
-
Homo sapiens
1.1.1.102 3-ketodihydrosphingosine reductase
-
Mus musculus
1.1.1.102 FVT-1
-
Homo sapiens
1.1.1.102 FVT-1
-
Mus musculus
1.1.1.102 h-FTV-1
-
Homo sapiens
1.1.1.102 KDS reductase
-
Homo sapiens
1.1.1.102 KDS reductase
-
Mus musculus
1.1.1.102 m-FTV-1
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.102 NADPH
-
Homo sapiens
1.1.1.102 NADPH
-
Mus musculus