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Literature summary extracted from

  • Matsuo, M.; Kurokawa, K.; Nishida, S.; Li, Y.; Takimura, H.; Kaito, C.; Fukuhara, N.; Maki, H.; Miura, K.; Murakami, K.; Sekimizu, K.
    Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus (2003), FEMS Microbiol. Lett., 222, 107-113.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.98 expressed in Escherichia coli and in host strain Staphylococcus aureus

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.98 E275K strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus
1.3.1.98 G251D strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus
1.3.1.98 G78D strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus
1.3.1.98 S243F strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.98 UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH Staphylococcus aureus essential for cell growth, functions in bacterial peptidoglycan biosynthesis UDP-N-acetyl-3-D-muramate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.98 Staphylococcus aureus Q54A20
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.98 UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
-
 Staphylococcus aureus UDP-N-acetyl-3-D-muramate + NADP+
-
 ?
1.3.1.98 UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH essential for cell growth, functions in bacterial peptidoglycan biosynthesis Staphylococcus aureus UDP-N-acetyl-3-D-muramate + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.98 FAD bound to protein Staphylococcus aureus
1.3.1.98 NADPH
-
 Staphylococcus aureus