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Literature summary extracted from

  • Jernejc, K.; Legisa, M.
    The influence of metal ions on malic enzyme activity and lipid synthesis in Aspergillus niger (2002), FEMS Microbiol. Lett., 217, 185-190.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.40 Cu2+ complete inhibition at 0.1 mM, competitive to Mg2+ and Mn2+, enzyme inhibition leads to reduced lipid biosynthesis and accumulation of citric acid, quantitative overview Aspergillus niger
1.1.1.40 Fe2+
-
 Aspergillus niger
1.1.1.40 Zn2+
-
 Aspergillus niger

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.40 Mg2+ Mn2+ or Mg2+ required Aspergillus niger
1.1.1.40 Mn2+ Mn2+ or Mg2+ required Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.40 additional information Aspergillus niger the enzyme is a supplier of reducing power in form of reduced NADPH for lipid biosynthesis ?
-
 ?
1.1.1.40 additional information Aspergillus niger NRRL 2270 the enzyme is a supplier of reducing power in form of reduced NADPH for lipid biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.40 Aspergillus niger
-
-
-
1.1.1.40 Aspergillus niger NRRL 2270
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.40 additional information
-
-
 Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.40 additional information the enzyme is a supplier of reducing power in form of reduced NADPH for lipid biosynthesis Aspergillus niger ?
-
 ?
1.1.1.40 additional information the enzyme is a supplier of reducing power in form of reduced NADPH for lipid biosynthesis Aspergillus niger NRRL 2270 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.40 malic enzyme
-
 Aspergillus niger

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.40 30
-
 assay at Aspergillus niger

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.40 7.4
-
 assay at Aspergillus niger

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.40 NADP+
-
 Aspergillus niger

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.40 0.01
-
 Cu2+ pH 7.4, 30°C, with Mg2+ Aspergillus niger
1.1.1.40 0.045
-
 Cu2+ pH 7.4, 30°C, with Mn2+ Aspergillus niger