EC Number | General Stability | Organism |
---|---|---|
1.1.1.42 | Mg2+ stabilizes the enzyme during purification | Fomitopsis palustris |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.42 | 2-oxoglutarate | 92% inhibition at 5 mM | Fomitopsis palustris | |
1.1.1.42 | ADP | 15% inhibition at 2 mM | Fomitopsis palustris | |
1.1.1.42 | ATP | 10% inhibition at 2 mM | Fomitopsis palustris | |
1.1.1.42 | Ca2+ | in presence of 5 mM Mg2+ 6% of maximal activity is remaining | Fomitopsis palustris | |
1.1.1.42 | Cd2+ | complete inhibition at 5 mM in presence of 5 mM Mg2+ | Fomitopsis palustris | |
1.1.1.42 | cis-aconitate | 35% inhibition at 5 mM | Fomitopsis palustris | |
1.1.1.42 | citrate | 30% inhibition at 1 mM and 5 mM | Fomitopsis palustris | |
1.1.1.42 | Co2+ | 92% inhibition in presence of 5 mM Mg2+ | Fomitopsis palustris | |
1.1.1.42 | Cu2+ | enzyme is completely inhibited at 5 mM in presence of 5 mM Mg2+, organism is a copper-tolerant basidiomycete | Fomitopsis palustris | |
1.1.1.42 | glyoxylate | 18% inhibition at 5 mM, mixed type inhibition together with oxaloacetate, completely at 5 mM each | Fomitopsis palustris | |
1.1.1.42 | Itaconate | 18% inhibition at 5 mM | Fomitopsis palustris | |
1.1.1.42 | additional information | AMP is a no inhibitor, no inhibition by glutamate, pyruvate and succinate | Fomitopsis palustris | |
1.1.1.42 | oxalate | 18% inhibition at 5 mM | Fomitopsis palustris | |
1.1.1.42 | oxaloacetate | 41% inhibition at 5 mM, mixed type inhibition together with glyoxylate, completely at 5 mM each | Fomitopsis palustris | |
1.1.1.42 | Zn2+ | complete inhibition at 5 mM in presence of 5 mM Mg2+ | Fomitopsis palustris |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.42 | 0.0029 | - |
NADP+ | pH 9.0, 30°C | Fomitopsis palustris | |
1.1.1.42 | 0.0127 | - |
isocitrate | pH 9.0, 30°C | Fomitopsis palustris | |
1.1.1.42 | 0.0239 | - |
Mg2+ | pH 9.0, 30°C | Fomitopsis palustris |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.42 | cytosol | - |
Fomitopsis palustris | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.42 | Co2+ | can substitute for Mg2+ by 25% | Fomitopsis palustris | |
1.1.1.42 | Mg2+ | required for activity | Fomitopsis palustris | |
1.1.1.42 | Mn2+ | can substitute for Mg2+ by 90% | Fomitopsis palustris | |
1.1.1.42 | additional information | K+ cannot substitute for Mg2+ | Fomitopsis palustris | |
1.1.1.42 | Na+ | can substitute for Mg2+ by 20% | Fomitopsis palustris |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.42 | 55000 | - |
2 * 55000, SDS-PAGE | Fomitopsis palustris |
1.1.1.42 | 115000 | - |
gel filtration | Fomitopsis palustris |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.42 | isocitrate + NADP+ | Fomitopsis palustris | key enzyme of the tricarboxylic acid cycle | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.42 | Fomitopsis palustris | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.42 | 672fold to homogeneity | Fomitopsis palustris |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.42 | mycelium | - |
Fomitopsis palustris | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.42 | 75 | - |
purified enzyme | Fomitopsis palustris |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.42 | DL-isocitrate + NADP+ | - |
Fomitopsis palustris | 2-oxoglutarate + CO2 + NADPH | - |
? | |
1.1.1.42 | isocitrate + NADP+ | key enzyme of the tricarboxylic acid cycle | Fomitopsis palustris | 2-oxoglutarate + CO2 + NADPH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.42 | dimer | 2 * 55000, SDS-PAGE | Fomitopsis palustris |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.42 | NADP-dependent isocitrate dehydrogenase | - |
Fomitopsis palustris |
1.1.1.42 | NADP-IDH | - |
Fomitopsis palustris |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.42 | 30 | - |
- |
Fomitopsis palustris |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.42 | 9 | - |
- |
Fomitopsis palustris |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.42 | NADP+ | - |
Fomitopsis palustris |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.42 | 0.127 | - |
2-oxoglutarate | pH 9.0, 30°C | Fomitopsis palustris |