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Literature summary extracted from

  • Kuroyanagi, M.; Shimamura, E.; Kim, M.; Arakawa, N.; Fujiwara, Y.; Otsuka, M.
    Effects of L-ascorbic acid on lysyl oxidase in the formation of collagen cross-links (2002), Biosci. Biotechnol. Biochem., 66, 2077-2082.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 3,4-dihydroxybenzoate
-
 Bos taurus
1.4.3.13 ascorbic acid inhibits the purified enzyme in vitro, and the formation of cross-linked collagen Bos taurus
1.4.3.13 erythorbic acid stereoisomer of ascorbic acid Bos taurus
1.4.3.13 glutathione slight inhibition Bos taurus
1.4.3.13 additional information no inhibition by dehydroascorbic acid Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.13 34000
-
 x * 34000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O Bos taurus deamination of lysyl and hydroxylysyl residues is part of the pyridinoline biosynthetic pathway, pyridinoline is involved in formation of intracellular and extracellular collagen cross-links responsible for aging of connective tissue peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.13 46.9fold from aorta by DEAE-cellulose ion exchange chromatography and gel filtration Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 aorta
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.13 1.2
-
 purified enzyme, substrate polylysine Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Bos taurus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O deamination of lysyl and hydroxylysyl residues is part of the pyridinoline biosynthetic pathway, pyridinoline is involved in formation of intracellular and extracellular collagen cross-links responsible for aging of connective tissue Bos taurus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 polylysine + O2 + H2O
-
 Bos taurus allysine + H2O2 + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.13 ? x * 34000, SDS-PAGE Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.13 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.13 7.8
-
 assay at Bos taurus