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Literature summary extracted from

  • Toda, M.; Kawabata, J.; Kasai, T.
    Inhibitory effects of ellagi- and gallotannins on rat intestinal alpha-glucosidase complexes (2001), Biosci. Biotechnol. Biochem., 65, 542-547.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.10 1,2,3-tri-O-galloyl-beta-D-glucose about 20% inhibition at 1 mM Rattus norvegicus
3.2.1.10 1-O-Galloyl-beta-D-glucose about 15% inhibition at 1 mM, 34.4% inhibition at 5 mM Rattus norvegicus
3.2.1.10 1-O-methyl-2,3-di-O-galloyl-beta-D-glucose about 10% inhibition at 1 mM Rattus norvegicus
3.2.1.10 casuarictin ellagtannin, from flower buds of Syzygium aromaticum, about 16% inhibition at 1 mM Rattus norvegicus
3.2.1.10 eugeniin ellagtannin, from flower buds of Syzygium aromaticum, about 18% inhibition at 1 mM Rattus norvegicus
3.2.1.10 gallic acid 8% inhibition at 5mM Rattus norvegicus
3.2.1.10 additional information structure-activity relationship study of inhibitors, inhibitory effect of the inhibitors on the different enzyme activities, such as maltase, sucrase and isomaltase activity, overview, an increasing number of galloyl units in the molecule leads to an increase in inhibitory potency Rattus norvegicus
3.2.1.10 penta-O-galloyl-beta-D-glucose about 40% inhibition at 1-5 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.10 membrane
-
 Rattus norvegicus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.10 Rattus norvegicus
-
 enzyme complex of sucrase and isomaltase integrated into the intestinal alpha-glucosidase function with the complex of maltase-glucoamylase
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.10 purification of the enzyme complex from rat intestinal acetone powder, by solubilization with Triton X-100, gel filtration, dialysis, ion exchange chromatography, and preparative PAGE Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.10 intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.10 4-methylumbelliferyl beta-D-glucoside + H2O
-
 Rattus norvegicus 4-methylumbelliferol + beta-D-glucose
-
 ?
3.2.1.10 sucrose + H2O
-
 Rattus norvegicus D-fructose + D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.10 S-I
-
 Rattus norvegicus
3.2.1.10 sucrase-isomaltase
-
 Rattus norvegicus