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Literature summary extracted from

  • Di Pietro, E.; Wang, X.L.; MacKenzie, R.E.
    The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth (2004), Biochim. Biophys. Acta, 1674, 78-84.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.15 additional information construction of a gene deletion mutant cell line, the cells can survive in liver and other tissues because the null defect is rescued by metabolites supplied by surrounding normal cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.15 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.15 5,10-methylenetetrahydrofolate + NAD+ Mus musculus enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview 5,10-methenyltetrahydrofolate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.15 Mus musculus P18155 gene nmdmc
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.15 embryo enzyme is mainly expressed during embryogenesis for purine synthesis Mus musculus
-
1.5.1.15 liver
-
 Mus musculus
-
1.5.1.15 additional information expression pattern analysis, elevated enzyme expression in tumour cells due to different folate-mediated support of purine synthesis compared to normal cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.15 5,10-methylenetetrahydrofolate + NAD+
-
 Mus musculus 5,10-methenyltetrahydrofolate + NADH
-
 ?
1.5.1.15 5,10-methylenetetrahydrofolate + NAD+ enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview Mus musculus 5,10-methenyltetrahydrofolate + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.15 methylenetetrahydrofolate dehydrogenase-cyclohydrolase
-
 Mus musculus
1.5.1.15 NMDMC
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.15 NAD+ dependent on Mus musculus