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Literature summary extracted from

  • Nakashima, K.; Ueno, N.; Kamei, D.; Tanioka, T.; Nakatani, Y.; Murakami, M.; Kudo, I.
    Coupling between cyclooxygenases and prostaglandin F(2alpha) synthase. Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F2alpha-synthetic activity (2003), Biochim. Biophys. Acta, 1633, 96-105.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.188 GSH
-
 Homo sapiens
1.1.1.188 interleukin-1beta membrane-associated, not soluble, isozyme in WI-38 cells Homo sapiens
1.1.1.188 lipopolysaccharide induces the membrane-associated isozyme Rattus norvegicus
1.1.1.188 lipopolysaccharides strong induction of the membrane-bound lung isozyme, slight induction in spleen, kidney, testis, and pancreas, overview Mus musculus
1.1.1.188 additional information PGF synthase I activity in HEK 293 cells is unaffected by interleukin-1beta Homo sapiens
1.1.1.189 lipopolysaccharides strong induction of the membrane-bound lung isozyme, significant induction in stomach, intestine, spleen, kidney, testis, and pancreas, overview Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.188 additional information coexpression of COX-1 and COX-2 increases the endogenous cytosolic PGFS-I activity, but only slightly the membrane-bound activity, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.188 FeCl2
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.188 cytosol not-inducible isozyme Rattus norvegicus 5829
-
1.1.1.188 cytosol not-inducible isozyme PGFS-I Homo sapiens 5829
-
1.1.1.188 membrane
-
 Mus musculus 16020
-
1.1.1.188 membrane inducible isozyme m-PGFS Homo sapiens 16020
-
1.1.1.188 membrane inducible isozyme m-PGFS Rattus norvegicus 16020
-
1.1.1.189 membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.188 additional information Rattus norvegicus enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 ?
-
 ?
1.1.1.188 additional information Homo sapiens the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 ?
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+ Mus musculus
-
 prostaglandin F2alpha + NADP+
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+ Homo sapiens
-
 prostaglandin F2alpha + NADP+
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+ Rattus norvegicus
-
 prostaglandin F2alpha + NADP+
-
 ?
1.1.1.189 prostaglandin H2 + NADPH + H+ Mus musculus
-
 prostaglandin F2alpha + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Homo sapiens
-
 2 isozymes PGFS-I and PGFS-II, soluble and membrane-associated isozymes
-
1.1.1.188 Mus musculus
-
-
-
1.1.1.188 Rattus norvegicus
-
 isozymes: 1 soluble not-inducible and 1 membraneous inducible by lipopolysaccharides
-
1.1.1.189 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 brain
-
 Mus musculus
-
1.1.1.188 GOTO cell glioblastoma cell Homo sapiens
-
1.1.1.188 heart
-
 Mus musculus
-
1.1.1.188 HEK-293 cell embryonic kidney cell, isozyme PGFS-I Homo sapiens
-
1.1.1.188 HeLa cell
-
 Homo sapiens
-
1.1.1.188 intestine
-
 Mus musculus
-
1.1.1.188 kidney
-
 Mus musculus
-
1.1.1.188 liver
-
 Mus musculus
-
1.1.1.188 lung
-
 Mus musculus
-
1.1.1.188 macrophage peritoneal Rattus norvegicus
-
1.1.1.188 pancreas
-
 Mus musculus
-
1.1.1.188 spleen
-
 Mus musculus
-
1.1.1.188 stomach
-
 Mus musculus
-
1.1.1.188 testis
-
 Mus musculus
-
1.1.1.188 thymus
-
 Mus musculus
-
1.1.1.188 U-251 cell glioblastoma cell Homo sapiens
-
1.1.1.188 WI-38 cell lung fibroblast cell Homo sapiens
-
1.1.1.189 brain
-
 Mus musculus
-
1.1.1.189 heart
-
 Mus musculus
-
1.1.1.189 intestine
-
 Mus musculus
-
1.1.1.189 kidney
-
 Mus musculus
-
1.1.1.189 liver
-
 Mus musculus
-
1.1.1.189 lung
-
 Mus musculus
-
1.1.1.189 pancreas
-
 Mus musculus
-
1.1.1.189 spleen
-
 Mus musculus
-
1.1.1.189 stomach
-
 Mus musculus
-
1.1.1.189 testis
-
 Mus musculus
-
1.1.1.189 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.188 additional information enzyme interacts with cyclooxygenase 1 and 2, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 Rattus norvegicus ?
-
 ?
1.1.1.188 additional information the cytosolic enzyme synergistically interacts with cyclooxygenase 1 and 2, coupling, isozyme PGFS-I interacts predominantly with cyclooxygenase 2, i.e. COX-2 Homo sapiens ?
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+
-
 Mus musculus prostaglandin F2alpha + NADP+
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+
-
 Homo sapiens prostaglandin F2alpha + NADP+
-
 ?
1.1.1.188 prostaglandin H2 + NADPH + H+
-
 Rattus norvegicus prostaglandin F2alpha + NADP+
-
 ?
1.1.1.189 prostaglandin H2 + NADPH + H+
-
 Mus musculus prostaglandin F2alpha + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.188 m-PGFS
-
 Mus musculus
1.1.1.188 m-PGFS
-
 Rattus norvegicus
1.1.1.188 PGF synthase
-
 Homo sapiens
1.1.1.188 PGF2alpha-synthetic activity
-
 Rattus norvegicus
1.1.1.188 PGFS
-
 Rattus norvegicus
1.1.1.188 prostaglandin F2alpha synthase
-
 Mus musculus
1.1.1.188 prostaglandin F2alpha synthase
-
 Homo sapiens
1.1.1.189 mPGES
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.188 24
-
 assay at Homo sapiens
1.1.1.188 24
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.188 8
-
 assay at Homo sapiens
1.1.1.188 8
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.188 NADPH
-
 Mus musculus
1.1.1.188 NADPH
-
 Homo sapiens
1.1.1.188 NADPH
-
 Rattus norvegicus
1.1.1.189 NADPH
-
 Mus musculus