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Literature summary extracted from
- Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase (2002), Biochemistry, 41, 15566-15577.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.55 | 8-oxo-dGMP | noncompetitive inhibitor of dGTP hydrolysis | Escherichia coli |  |
| 3.6.1.55 | dGMP | noncompetitive inhibitor of dGTP hydrolysis | Escherichia coli | |
| 3.6.1.55 | diphosphate | linear uncompetitive inhibitor of dGTP hydrolysis | Escherichia coli | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.55 | Mg2+ | activates | Escherichia coli | |
| 3.6.1.55 | Mn2+ | activates | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.55 | 8-oxo-dGTP + H2O | Escherichia coli | - |
8-oxo-dGMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.55 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.55 | 8-oxo-dGTP + H2O | - |
Escherichia coli | 8-oxo-dGMP + diphosphate | - |
? | |
| 3.6.1.55 | 8-oxo-dGTP + H2O | the unusually high affinity of MutT for 8-oxo-nucleotides is due not only to interactions with the altered 8-oxo or 7-NH positions on guanine, but results primarily from diffuse structural changes which tighten the protein structure around the 8-oxo-nucleotide | Escherichia coli | 8-oxo-dGMP + diphosphate | - |
? | |
| 3.6.1.55 | dGTP + H2O | - |
Escherichia coli | dGMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.55 | MutT | - |
Escherichia coli |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.55 | 23 | - |
assay at | Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.55 | 7.5 | - |
assay at | Escherichia coli |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.6.1.55 | 0.000049 | - |
8-oxo-dGMP | pH 7.5, 23°C, Mg2+-activated, Ki(slope) | Escherichia coli | |
| 3.6.1.55 | 0.000173 | - |
8-oxo-dGMP | pH 7.5, 23°C, Mn2+-activated, Ki(slope) | Escherichia coli | |
| 3.6.1.55 | 0.000593 | - |
8-oxo-dGMP | pH 7.5, 23°C, Mn2+-activated, Ki(intercept) | Escherichia coli | |
| 3.6.1.55 | 0.00162 | - |
8-oxo-dGMP | pH 7.5, 23°C, Mg2+-activated, Ki(intercept) | Escherichia coli | |
| 3.6.1.55 | 0.413 | - |
diphosphate | pH 7.5, 23°C, Mn2+-activated, Ki(intercept) | Escherichia coli | |
| 3.6.1.55 | 1.74 | - |
dGMP | pH 7.5, 23°C, Mg2+-activated, Ki(slope) | Escherichia coli | |
| 3.6.1.55 | 3.96 | - |
dGMP | pH 7.5, 23°C, Mn2+-activated, Ki(slope) | Escherichia coli | |
| 3.6.1.55 | 4.57 | - |
dGMP | pH 7.5, 23°C, Mn2+-activated, Ki(intercept) | Escherichia coli | |
| 3.6.1.55 | 4.95 | - |
diphosphate | pH 7.5, 23°C, Mg2+-activated, Ki(intercept) | Escherichia coli | |
| 3.6.1.55 | 14.5 | - |
dGMP | pH 7.5, 23°C, Mg2+-activated, Ki(intercept) | Escherichia coli | |
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