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Literature summary extracted from

  • Guranowski, A.; Starzynska, E.; McLennan, A.G.; Baraniak, J.; Stec, W.J.
    Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases (2003), Biochem. J., 373, 635-640.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.41 expression of a His-tagged protein in Escherichia coli Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.17 1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
-
 Homo sapiens
3.6.1.17 1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
 Homo sapiens
3.6.1.17 1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
 Lupinus angustifolius
3.6.1.17 1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
 Homo sapiens
3.6.1.17 1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
 Lupinus angustifolius
3.6.1.17 1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
-
 Homo sapiens
3.6.1.17 1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
 Homo sapiens
3.6.1.17 1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
 Lupinus angustifolius
3.6.1.17 1,3-di(adenosine-5'-O-phospho)glycerol
-
 Homo sapiens
3.6.1.17 1,4-di(adenosine-5'-O-phospho)erythritol
-
 Homo sapiens
3.6.1.17 1,4-di(adenosine-5'-O-phospho)erythritol
-
 Lupinus angustifolius
3.6.1.17 1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
 Homo sapiens
3.6.1.17 1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
 Lupinus angustifolius
3.6.1.17 di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
-
 Homo sapiens
3.6.1.41 1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
-
 Escherichia coli
3.6.1.41 1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol competitive with respect to Ap4A Escherichia coli
3.6.1.41 1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 1,2,3-tri(adenosine-5'-O-phospho) glycerol
-
 Escherichia coli
3.6.1.41 1,3-di(adenosine-5'-O-phospho) glycerol
-
 Escherichia coli
3.6.1.41 1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
-
 Escherichia coli
3.6.1.41 1,3-di(adenosine-5'-O-phosphorothio) glycerol
-
 Escherichia coli
3.6.1.41 1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
 Escherichia coli
3.6.1.41 1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 1,4-di(adenosine-5'-O-phosphorothio) butanediol
-
 Escherichia coli
3.6.1.41 1,4-di(adenosine-5'-O-phosphorothio) erythritol
-
 Escherichia coli
3.6.1.41 1,5-di(adenosine-5'-O-phosphorothio) pentanediol
-
 Escherichia coli
3.6.1.41 di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
-
 Escherichia coli
3.6.1.41 di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol competitive with respect to Ap4A Escherichia coli
3.6.1.41 di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 tetra(adenosine-5'-O-phospho) pentaerythritol
-
 Escherichia coli
3.6.1.41 tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
 Escherichia coli
3.6.1.41 tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 tri(adenosine-5'-O-phospho)-phospho pentaerythritol
-
 Escherichia coli
3.6.1.41 tri(adenosine-5'-O-phosphorothio) glycerol
-
 Escherichia coli
3.6.1.41 tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
 Escherichia coli
3.6.1.41 tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
 Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.41 0.005
-
 P1,P4-bis(5'-adenosyl) tetraphosphate pH 7.6, 30°C Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 0.025
-
 P1,P4-bis(5'-adenosyl) tetraphosphate pH 7.6, 30°C Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.17 Homo sapiens
-
-
-
3.6.1.17 Lupinus angustifolius
-
-
-
3.6.1.41 Escherichia coli
-
 K12 strain
-
3.6.1.41 Salmonella enterica subsp. enterica serovar Typhimurium
-
 LT2 strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.41 using Ni-affinity column chromatography to isolate a His-tagged recombinant enzyme Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.17 diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Homo sapiens ATP + AMP
-
 ?
3.6.1.17 diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Lupinus angustifolius ATP + AMP
-
 ?
3.6.1.41 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2 ADP
-
 ?
3.6.1.41 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O hydrolysis of Ap4A Escherichia coli 2 ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.17 (asymmetrical) dinucleoside tetraphosphatase
-
 Homo sapiens
3.6.1.17 (asymmetrical) dinucleoside tetraphosphatase
-
 Lupinus angustifolius
3.6.1.17 Ap4A hydrolase
-
 Homo sapiens
3.6.1.17 Ap4A hydrolase
-
 Lupinus angustifolius
3.6.1.41 (symmetrical) Ap4A hydrolase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 (symmetrical) Ap4A hydrolase
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.17 0.00015
-
 1,4-di(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Lupinus angustifolius
3.6.1.17 0.0015
-
 1,4-di(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.0037
-
 di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.0085
-
 1,4-di(adenosine-5'-O-phospho)erythritol pH 7.6, 30°C Lupinus angustifolius
3.6.1.17 0.013
-
 1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Lupinus angustifolius
3.6.1.17 0.017
-
 1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol pH 7.6, 30°C Lupinus angustifolius
3.6.1.17 0.018
-
 1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.025
-
 1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol pH 7.6, 30°C Lupinus angustifolius
3.6.1.17 0.031
-
 1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.032
-
 1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.037
-
 1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.066
-
 1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.109
-
 1,3-di(adenosine-5'-O-phospho)glycerol pH 7.6, 30°C Homo sapiens
3.6.1.17 0.142
-
 1,4-di(adenosine-5'-O-phospho)erythritol pH 7.6, 30°C Homo sapiens
3.6.1.41 0.00002
-
 di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol pH 7.6, 30°C Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 0.00004
-
 di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.00008
-
 tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.001
-
 di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.0013
-
 1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.0014
-
 1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.0014
-
 tetra(adenosine-5'-O-phosphorothio) pentaerythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.0017
-
 tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol pH 7.6, 30°C Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 0.0018
-
 tetra(adenosine-5'-O-phosphorothio) pentaerythritol pH 7.6, 30°C Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 0.0029
-
 1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol pH 7.6, 30°C Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 0.003
-
 tri(adenosine-5'-O-phospho)-phospho pentaerythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.0039
-
 1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol pH 7.6, 30°C Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41 0.005
-
 1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.006
-
 1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.007
-
 tri(adenosine-5'-O-phosphorothio) glycerol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.028
-
 tetra(adenosine-5'-O-phospho) pentaerythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.078
-
 1,4-di(adenosine-5'-O-phosphorothio) erythritol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.089
-
 1,4-di(adenosine-5'-O-phosphorothio) butanediol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.109
-
 1,5-di(adenosine-5'-O-phosphorothio) pentanediol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.157
-
 1,3-di(adenosine-5'-O-phosphorothio) glycerol pH 7.6, 30°C Escherichia coli
3.6.1.41 0.215
-
 1,3-di(adenosine-5'-O-phospho) glycerol pH 7.6, 30°C Escherichia coli
3.6.1.41 4.08
-
 1,2,3-tri(adenosine-5'-O-phospho) glycerol pH 7.6, 30°C Escherichia coli